This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2y71
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | == | + | |
| - | <StructureSection load='2y71' size='340' side='right' caption='[[2y71]], [[Resolution|resolution]] 1.50Å' scene=''> | + | ==Structure of Mycobacterium tuberculosis type II dehydroquinase complexed with (1R,4S,5R)-1,4,5-trihydroxy-3-((5-methylbenzo(b) thiophen-2-yl)methoxy)cyclohex-2-enecarboxylate== |
| + | <StructureSection load='2y71' size='340' side='right'caption='[[2y71]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y71]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2y71]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y71 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB6:(1R,4S,5R)-1,4,5-TRIHYDROXY-3-[(5-METHYL-1-BENZOTHIOPHEN-2-YL)METHOXY]CYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>CB6</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y71 OCA], [https://pdbe.org/2y71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y71 RCSB], [https://www.ebi.ac.uk/pdbsum/2y71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y71 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 14: | Line 16: | ||
A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors.,Tizon L, Otero JM, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Ainsa JA, Castedo L, Gonzalez-Bello C J Med Chem. 2011 Aug 3. PMID:21780742<ref>PMID:21780742</ref> | A Prodrug Approach for Improving Antituberculosis Activity of Potent Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors.,Tizon L, Otero JM, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Ainsa JA, Castedo L, Gonzalez-Bello C J Med Chem. 2011 Aug 3. PMID:21780742<ref>PMID:21780742</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 2y71" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: Ainsa | + | [[Category: Ainsa JA]] |
| - | [[Category: Castedo | + | [[Category: Castedo L]] |
| - | [[Category: Fox | + | [[Category: Fox GC]] |
| - | [[Category: Gonzalez-Bello | + | [[Category: Gonzalez-Bello C]] |
| - | [[Category: Hawkins | + | [[Category: Hawkins AR]] |
| - | [[Category: Lamb | + | [[Category: Lamb H]] |
| - | [[Category: Llamas-Saiz | + | [[Category: Llamas-Saiz AL]] |
| - | [[Category: Otero | + | [[Category: Otero JM]] |
| - | [[Category: Prazeres | + | [[Category: Prazeres VFV]] |
| - | + | [[Category: Tizon L]] | |
| - | [[Category: Tizon | + | [[Category: Van Raaij MJ]] |
| - | [[Category: | + | |
| - | + | ||
Current revision
Structure of Mycobacterium tuberculosis type II dehydroquinase complexed with (1R,4S,5R)-1,4,5-trihydroxy-3-((5-methylbenzo(b) thiophen-2-yl)methoxy)cyclohex-2-enecarboxylate
| |||||||||||
