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2xmq

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==CRYSTAL STRUCTURE OF HUMAN NDRG2 PROTEIN PROVIDES INSIGHT INTO ITS ROLE AS A TUMOR SUPPRESSOR==
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<StructureSection load='2xmq' size='340' side='right' caption='[[2xmq]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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==Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor==
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<StructureSection load='2xmq' size='340' side='right'caption='[[2xmq]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xmq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XMQ OCA]. <br>
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<table><tr><td colspan='2'>[[2xmq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XMQ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xmr|2xmr]], [[2xms|2xms]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xmq OCA], [https://pdbe.org/2xmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xmq RCSB], [https://www.ebi.ac.uk/pdbsum/2xmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xmq ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xmq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xmq RCSB], [http://www.ebi.ac.uk/pdbsum/2xmq PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/NDRG2_HUMAN NDRG2_HUMAN] Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.<ref>PMID:12845671</ref> <ref>PMID:16103061</ref> <ref>PMID:21247902</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor.,Hwang J, Kim Y, Kang HB, Jaroszewski L, Deacon A, Lee H, Choi WC, Kim KJ, Kim CH, Kang BS, Lee JO, Oh TK, Kim JW, Wilson IA, Kim MH J Biol Chem. 2011 Jan 18. PMID:21247902<ref>PMID:21247902</ref>
Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor.,Hwang J, Kim Y, Kang HB, Jaroszewski L, Deacon A, Lee H, Choi WC, Kim KJ, Kim CH, Kang BS, Lee JO, Oh TK, Kim JW, Wilson IA, Kim MH J Biol Chem. 2011 Jan 18. PMID:21247902<ref>PMID:21247902</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2xmq" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hwang, J.]]
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[[Category: Large Structures]]
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[[Category: Kim, M H.]]
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[[Category: Hwang J]]
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[[Category: Kim, Y.]]
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[[Category: Kim MH]]
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[[Category: Lee, H.]]
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[[Category: Kim Y]]
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[[Category: Signaling protein]]
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[[Category: Lee H]]

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Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor

PDB ID 2xmq

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