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2ykq

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==STRUCTURE OF THE HUMAN LINE-1 ORF1P TRIMER==
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<StructureSection load='2ykq' size='340' side='right' caption='[[2ykq]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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==Structure of the human LINE-1 ORF1p trimer==
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<StructureSection load='2ykq' size='340' side='right'caption='[[2ykq]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ykq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKQ OCA]. <br>
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<table><tr><td colspan='2'>[[2ykq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YKQ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2w7a|2w7a]], [[2jrb|2jrb]], [[2yko|2yko]], [[2ldy|2ldy]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ykq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykq OCA], [https://pdbe.org/2ykq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ykq RCSB], [https://www.ebi.ac.uk/pdbsum/2ykq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ykq ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ykq RCSB], [http://www.ebi.ac.uk/pdbsum/2ykq PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/LORF1_HUMAN LORF1_HUMAN] Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. May function as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.<ref>PMID:11158327</ref> <ref>PMID:21937507</ref> <ref>PMID:8945518</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition.,Khazina E, Truffault V, Buttner R, Schmidt S, Coles M, Weichenrieder O Nat Struct Mol Biol. 2011 Aug 7. doi: 10.1038/nsmb.2097. PMID:21822284<ref>PMID:21822284</ref>
Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition.,Khazina E, Truffault V, Buttner R, Schmidt S, Coles M, Weichenrieder O Nat Struct Mol Biol. 2011 Aug 7. doi: 10.1038/nsmb.2097. PMID:21822284<ref>PMID:21822284</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2ykq" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Khazina, E.]]
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[[Category: Large Structures]]
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[[Category: Weichenrieder, O.]]
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[[Category: Khazina E]]
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[[Category: Coiled-coil]]
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[[Category: Weichenrieder O]]
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[[Category: Genome evolution]]
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[[Category: Nucleic acid chaperone]]
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[[Category: Rna-binding protein]]
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[[Category: Rnp]]
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Current revision

Structure of the human LINE-1 ORF1p trimer

PDB ID 2ykq

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