2y75

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==THE STRUCTURE OF CYMR (YRZC) THE GLOBAL CYSTEINE REGULATOR OF B. SUBTILIS==
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<StructureSection load='2y75' size='340' side='right' caption='[[2y75]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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==The Structure of CymR (YrzC) the Global Cysteine Regulator of B. subtilis==
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<StructureSection load='2y75' size='340' side='right'caption='[[2y75]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. <br>
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<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [http://www.ebi.ac.uk/pdbsum/2y75 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [https://pdbe.org/2y75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [https://www.ebi.ac.uk/pdbsum/2y75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y75 ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYMR_BACSU CYMR_BACSU] Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression.<ref>PMID:16513748</ref> <ref>PMID:18974048</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Insights into the Rrf2 repressor family - the structure of CymR, the global cysteine regulator of Bacillus subtilis.,Shepard W, Soutourina O, Courtois E, England P, Haouz A, Martin-Verstraete I FEBS J. 2011 Aug;278(15):2689-701. doi: 10.1111/j.1742-4658.2011.08195.x., Epub 2011 Jul 1. PMID:21624051<ref>PMID:21624051</ref>
Insights into the Rrf2 repressor family - the structure of CymR, the global cysteine regulator of Bacillus subtilis.,Shepard W, Soutourina O, Courtois E, England P, Haouz A, Martin-Verstraete I FEBS J. 2011 Aug;278(15):2689-701. doi: 10.1111/j.1742-4658.2011.08195.x., Epub 2011 Jul 1. PMID:21624051<ref>PMID:21624051</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2y75" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Courtois, E.]]
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[[Category: Large Structures]]
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[[Category: England, P.]]
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[[Category: Courtois E]]
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[[Category: Haouz, A.]]
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[[Category: England P]]
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[[Category: Martin-Verstraete, I.]]
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[[Category: Haouz A]]
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[[Category: Shepard, W.]]
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[[Category: Martin-Verstraete I]]
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[[Category: Soutourina, O.]]
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[[Category: Shepard W]]
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[[Category: Dna binding protein]]
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[[Category: Soutourina O]]
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[[Category: Transcription]]
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Current revision

The Structure of CymR (YrzC) the Global Cysteine Regulator of B. subtilis

PDB ID 2y75

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