2yly
From Proteopedia
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==Sulfonamides as selective Estrogen Receptor beta Agonists.== | ==Sulfonamides as selective Estrogen Receptor beta Agonists.== | ||
| - | <StructureSection load='2yly' size='340' side='right' caption='[[2yly]], [[Resolution|resolution]] 3.20Å' scene=''> | + | <StructureSection load='2yly' size='340' side='right'caption='[[2yly]], [[Resolution|resolution]] 3.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yly]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2yly]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLY FirstGlance]. <br> |
| - | </ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SU4:N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL-2-PHENYL-PROPYL]BENZENESULFONAMIDE'>SU4</scene></td></tr> | |
| - | <tr><td class="sblockLbl"><b> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yly OCA], [https://pdbe.org/2yly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yly RCSB], [https://www.ebi.ac.uk/pdbsum/2yly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yly ProSAT]</span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Sulfonamides as selective oestrogen receptor beta agonists.,Roberts LR, Armor D, Barker C, Bent A, Bess K, Brown A, Favor DA, Ellis D, Irving SL, MacKenny M, Phillips C, Pullen N, Stennett A, Strand L, Styles M Bioorg Med Chem Lett. 2011 Oct 1;21(19):5680-3. Epub 2011 Aug 16. PMID:21885279<ref>PMID:21885279</ref> | Sulfonamides as selective oestrogen receptor beta agonists.,Roberts LR, Armor D, Barker C, Bent A, Bess K, Brown A, Favor DA, Ellis D, Irving SL, MacKenny M, Phillips C, Pullen N, Stennett A, Strand L, Styles M Bioorg Med Chem Lett. 2011 Oct 1;21(19):5680-3. Epub 2011 Aug 16. PMID:21885279<ref>PMID:21885279</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 2yly" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Armour | + | [[Category: Large Structures]] |
| - | [[Category: Barker | + | [[Category: Armour D]] |
| - | [[Category: Bazin | + | [[Category: Barker C]] |
| - | [[Category: Bess | + | [[Category: Bazin R]] |
| - | [[Category: Brown | + | [[Category: Bess K]] |
| - | [[Category: Ellis | + | [[Category: Brown A]] |
| - | [[Category: Favor | + | [[Category: Ellis D]] |
| - | [[Category: | + | [[Category: Favor D]] |
| - | [[Category: Phillips | + | [[Category: MacKenny M]] |
| - | [[Category: Pullen | + | [[Category: Phillips C]] |
| - | [[Category: Roberts | + | [[Category: Pullen N]] |
| - | [[Category: Stennett | + | [[Category: Roberts LR]] |
| - | [[Category: Strand | + | [[Category: Stennett A]] |
| - | [[Category: Styles | + | [[Category: Strand L]] |
| - | + | [[Category: Styles M]] | |
Current revision
Sulfonamides as selective Estrogen Receptor beta Agonists.
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Categories: Homo sapiens | Large Structures | Armour D | Barker C | Bazin R | Bess K | Brown A | Ellis D | Favor D | MacKenny M | Phillips C | Pullen N | Roberts LR | Stennett A | Strand L | Styles M
