2ygb
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2ygb' size='340' side='right' caption='[[2ygb]], [[Resolution|resolution]] 2.81Å' scene=''> | + | ==Structure of vaccinia virus D13 scaffolding protein== |
| + | <StructureSection load='2ygb' size='340' side='right'caption='[[2ygb]], [[Resolution|resolution]] 2.81Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ygb]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ygb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Western_Reserve Vaccinia virus Western Reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YGB FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ygb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygb OCA], [https://pdbe.org/2ygb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ygb RCSB], [https://www.ebi.ac.uk/pdbsum/2ygb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ygb ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/D13_VACCW D13_VACCW] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Insights into the evolution of a complex virus from the crystal structure of vaccinia virus d13.,Bahar MW, Graham SC, Stuart DI, Grimes JM Structure. 2011 Jul 13;19(7):1011-20. PMID:21742267<ref>PMID:21742267</ref> | Insights into the evolution of a complex virus from the crystal structure of vaccinia virus d13.,Bahar MW, Graham SC, Stuart DI, Grimes JM Structure. 2011 Jul 13;19(7):1011-20. PMID:21742267<ref>PMID:21742267</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 2ygb" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Vaccinia virus Western Reserve]] |
| - | [[Category: | + | [[Category: Bahar MW]] |
| - | [[Category: | + | [[Category: Graham SC]] |
| - | [[Category: | + | [[Category: Grimes JM]] |
| - | [[Category: | + | [[Category: Stuart DI]] |
| - | + | ||
Current revision
Structure of vaccinia virus D13 scaffolding protein
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