2xse
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2xse' size='340' side='right' caption='[[2xse]], [[Resolution|resolution]] 1.90Å' scene=''> | + | ==The structural basis for recognition of J-base containing DNA by a novel DNA-binding domain in JBP1== |
| + | <StructureSection load='2xse' size='340' side='right'caption='[[2xse]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xse]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2xse]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_tarentolae Leishmania tarentolae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XSE FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xse OCA], [https://pdbe.org/2xse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xse RCSB], [https://www.ebi.ac.uk/pdbsum/2xse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xse ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/JBP1_LEITA JBP1_LEITA] Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions.<ref>PMID:17389644</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1.,Heidebrecht T, Christodoulou E, Chalmers MJ, Jan S, Ter Riet B, Grover RK, Joosten RP, Littler D, van Luenen H, Griffin PR, Wentworth P Jr, Borst P, Perrakis A Nucleic Acids Res. 2011 Mar 16. PMID:21415010<ref>PMID:21415010</ref> | The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1.,Heidebrecht T, Christodoulou E, Chalmers MJ, Jan S, Ter Riet B, Grover RK, Joosten RP, Littler D, van Luenen H, Griffin PR, Wentworth P Jr, Borst P, Perrakis A Nucleic Acids Res. 2011 Mar 16. PMID:21415010<ref>PMID:21415010</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 2xse" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dioxygenase 3D structures|Dioxygenase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Leishmania tarentolae]] | [[Category: Leishmania tarentolae]] | ||
| - | + | [[Category: Borst P]] | |
| - | [[Category: Borst | + | [[Category: Chalmers MJ]] |
| - | [[Category: Chalmers | + | [[Category: Christodoulou E]] |
| - | [[Category: Christodoulou | + | [[Category: Griffin PR]] |
| - | [[Category: Griffin | + | [[Category: Grover RK]] |
| - | [[Category: Grover | + | [[Category: Heidebrecht T]] |
| - | [[Category: Heidebrecht | + | [[Category: Jan S]] |
| - | [[Category: Jan | + | [[Category: Joosten RP]] |
| - | [[Category: Joosten | + | [[Category: Littler D]] |
| - | [[Category: Littler | + | [[Category: Perrakis A]] |
| - | [[Category: Perrakis | + | [[Category: Wentworth P]] |
| - | + | [[Category: Ter Riete B]] | |
| - | + | [[Category: VanLuenen H]] | |
| - | [[Category: Wentworth | + | |
| - | [[Category: | + | |
| - | [[Category: | + | |
Current revision
The structural basis for recognition of J-base containing DNA by a novel DNA-binding domain in JBP1
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