2xuz

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==Crystal structure of the triscatecholate siderophore binding protein FeuA from Bacillus subtilis complexed with Ferri-Enterobactin==
==Crystal structure of the triscatecholate siderophore binding protein FeuA from Bacillus subtilis complexed with Ferri-Enterobactin==
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<StructureSection load='2xuz' size='340' side='right' caption='[[2xuz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='2xuz' size='340' side='right'caption='[[2xuz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xuz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUZ OCA]. <br>
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<table><tr><td colspan='2'>[[2xuz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUZ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2why|2why]], [[2xv1|2xv1]], [[2wi8|2wi8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xuz OCA], [https://pdbe.org/2xuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xuz RCSB], [https://www.ebi.ac.uk/pdbsum/2xuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xuz ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xuz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xuz RCSB], [http://www.ebi.ac.uk/pdbsum/2xuz PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/FEUA_BACSU FEUA_BACSU] Involved in the uptake of iron.<ref>PMID:16672620</ref> Part of the ABC transporter complex FeuABC/YusV involved in import of the catecholate siderophores bacillibactin and enterobactin (Probable).<ref>PMID:16672620</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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The siderophore binding protein FeuA shows limited promiscuity toward exogenous triscatecholates.,Peuckert F, Ramos-Vega AL, Miethke M, Schworer CJ, Albrecht AG, Oberthur M, Marahiel MA Chem Biol. 2011 Jul 29;18(7):907-19. PMID:21802011<ref>PMID:21802011</ref>
The siderophore binding protein FeuA shows limited promiscuity toward exogenous triscatecholates.,Peuckert F, Ramos-Vega AL, Miethke M, Schworer CJ, Albrecht AG, Oberthur M, Marahiel MA Chem Biol. 2011 Jul 29;18(7):907-19. PMID:21802011<ref>PMID:21802011</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2xuz" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Albrecht, A G.]]
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[[Category: Large Structures]]
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[[Category: Marahiel, M A.]]
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[[Category: Albrecht AG]]
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[[Category: Miethke, M.]]
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[[Category: Marahiel MA]]
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[[Category: Oberthuer, M.]]
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[[Category: Miethke M]]
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[[Category: Peuckert, F.]]
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[[Category: Oberthuer M]]
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[[Category: Schwoerer, C J.]]
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[[Category: Peuckert F]]
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[[Category: Bacillibactin and enterobactin binding]]
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[[Category: Schwoerer CJ]]
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[[Category: High affinity iron import]]
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[[Category: Iron transport]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of the triscatecholate siderophore binding protein FeuA from Bacillus subtilis complexed with Ferri-Enterobactin

PDB ID 2xuz

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