2ww5

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==3D-STRUCTURE OF THE MODULAR AUTOLYSIN LYTC FROM STREPTOCOCCUS PNEUMONIAE AT 1.6 A RESOLUTION==
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<StructureSection load='2ww5' size='340' side='right' caption='[[2ww5]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
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==3D-structure of the modular autolysin LytC from Streptococcus pneumoniae at 1.6 A resolution==
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<StructureSection load='2ww5' size='340' side='right'caption='[[2ww5]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ww5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WW5 OCA]. <br>
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<table><tr><td colspan='2'>[[2ww5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WW5 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CHT:CHOLINE+ION'>CHT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wwd|2wwd]], [[2wwc|2wwc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHT:CHOLINE+ION'>CHT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ww5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ww5 OCA], [https://pdbe.org/2ww5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ww5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ww5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ww5 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ww5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ww5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ww5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ww5 PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8DP07_STRR6 Q8DP07_STRR6]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2ww5_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2ww5_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ww5 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC.,Perez-Dorado I, Gonzalez A, Morales M, Sanles R, Striker W, Vollmer W, Mobashery S, Garcia JL, Martinez-Ripoll M, Garcia P, Hermoso JA Nat Struct Mol Biol. 2010 May;17(5):576-81. Epub 2010 Apr 18. PMID:20400948<ref>PMID:20400948</ref>
Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC.,Perez-Dorado I, Gonzalez A, Morales M, Sanles R, Striker W, Vollmer W, Mobashery S, Garcia JL, Martinez-Ripoll M, Garcia P, Hermoso JA Nat Struct Mol Biol. 2010 May;17(5):576-81. Epub 2010 Apr 18. PMID:20400948<ref>PMID:20400948</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2ww5" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Streptococcus pneumoniae]]
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[[Category: Streptococcus pneumoniae R6]]
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[[Category: Garcia, A.]]
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[[Category: Garcia A]]
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[[Category: Garcia, J L.]]
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[[Category: Garcia JL]]
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[[Category: Garcia, P.]]
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[[Category: Garcia P]]
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[[Category: Gonzalez, A.]]
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[[Category: Gonzalez A]]
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[[Category: Hermoso, J A.]]
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[[Category: Hermoso JA]]
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[[Category: Menendez, M.]]
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[[Category: Menendez M]]
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[[Category: Perez-Dorado, I.]]
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[[Category: Perez-Dorado I]]
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[[Category: Sanles, R.]]
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[[Category: Sanles R]]
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[[Category: Choline-binding protein]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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Current revision

3D-structure of the modular autolysin LytC from Streptococcus pneumoniae at 1.6 A resolution

PDB ID 2ww5

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