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2y66
From Proteopedia
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| - | <StructureSection load='2y66' size='340' side='right' caption='[[2y66]], [[Resolution|resolution]] 1.49Å' scene=''> | + | ==New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation== |
| + | <StructureSection load='2y66' size='340' side='right'caption='[[2y66]], [[Resolution|resolution]] 1.49Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y66]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2y66]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y66 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=N04:(2R)-2-[[3-[[3-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]PHENOXY]METHYL]PHENYL]CARBONYLAMINO]PENTANEDIOIC+ACID'>N04</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4 | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=N04:(2R)-2-[[3-[[3-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]PHENOXY]METHYL]PHENYL]CARBONYLAMINO]PENTANEDIOIC+ACID'>N04</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y66 OCA], [https://pdbe.org/2y66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y66 RCSB], [https://www.ebi.ac.uk/pdbsum/2y66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y66 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | <table> | + | [https://www.uniprot.org/uniprot/MURD_ECOLI MURD_ECOLI] Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).[HAMAP-Rule:MF_00639] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: Design, synthesis, crystal structures, and biological evaluation.,Zidar N, Tomasic T, Sink R, Kovac A, Patin D, Blanot D, Contreras-Martel C, Dessen A, Premru MM, Zega A, Gobec S, Masic LP, Kikelj D Eur J Med Chem. 2011 Sep 17. PMID:21963114<ref>PMID:21963114</ref> | New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: Design, synthesis, crystal structures, and biological evaluation.,Zidar N, Tomasic T, Sink R, Kovac A, Patin D, Blanot D, Contreras-Martel C, Dessen A, Premru MM, Zega A, Gobec S, Masic LP, Kikelj D Eur J Med Chem. 2011 Sep 17. PMID:21963114<ref>PMID:21963114</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 2y66" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Mur ligase|Mur ligase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Escherichia coli]] | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Blanot | + | [[Category: Blanot D]] |
| - | [[Category: Contreras-Martel | + | [[Category: Contreras-Martel C]] |
| - | [[Category: Dessen | + | [[Category: Dessen A]] |
| - | [[Category: Gobec | + | [[Category: Gobec S]] |
| - | [[Category: Kikelj | + | [[Category: Kikelj D]] |
| - | [[Category: Kovac | + | [[Category: Kovac A]] |
| - | [[Category: Muller-Premru | + | [[Category: Muller-Premru M]] |
| - | [[Category: Patin | + | [[Category: Patin D]] |
| - | [[Category: Peterlin-Masic | + | [[Category: Peterlin-Masic L]] |
| - | [[Category: Sink | + | [[Category: Sink R]] |
| - | [[Category: Tomasic | + | [[Category: Tomasic T]] |
| - | [[Category: Zega | + | [[Category: Zega A]] |
| - | [[Category: Zidar | + | [[Category: Zidar N]] |
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Current revision
New 5-Benzylidenethiazolidine-4-one Inhibitors of Bacterial MurD Ligase: Design, Synthesis, Crystal Structures, and Biological Evaluation
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Categories: Escherichia coli K-12 | Large Structures | Blanot D | Contreras-Martel C | Dessen A | Gobec S | Kikelj D | Kovac A | Muller-Premru M | Patin D | Peterlin-Masic L | Sink R | Tomasic T | Zega A | Zidar N
