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2xc7
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2xc7' size='340' side='right' caption='[[2xc7]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | ==Solution Structure of PHAX-RBD in complex with ssRNA== |
| + | <StructureSection load='2xc7' size='340' side='right'caption='[[2xc7]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xc7]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2xc7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XC7 FirstGlance]. <br> |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xc7 OCA], [https://pdbe.org/2xc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xc7 RCSB], [https://www.ebi.ac.uk/pdbsum/2xc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xc7 ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| + | [[https://www.uniprot.org/uniprot/PHAX_HUMAN PHAX_HUMAN]] A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.<ref>PMID:15574332</ref> <ref>PMID:15574333</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xc/2xc7_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xc/2xc7_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xc7 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX.,Mourao A, Varrot A, Mackereth CD, Cusack S, Sattler M RNA. 2010 Jun;16(6):1205-16. Epub 2010 Apr 29. PMID:20430857<ref>PMID:20430857</ref> | Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX.,Mourao A, Varrot A, Mackereth CD, Cusack S, Sattler M RNA. 2010 Jun;16(6):1205-16. Epub 2010 Apr 29. PMID:20430857<ref>PMID:20430857</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 2xc7" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Cusack, S | + | [[Category: Large Structures]] |
| - | [[Category: Mackereth, C D | + | [[Category: Cusack, S]] |
| - | [[Category: Mourao, A | + | [[Category: Mackereth, C D]] |
| - | [[Category: Sattler, M | + | [[Category: Mourao, A]] |
| - | [[Category: Varrot, A | + | [[Category: Sattler, M]] |
| + | [[Category: Varrot, A]] | ||
[[Category: Nuclear export]] | [[Category: Nuclear export]] | ||
[[Category: Protein-rna complex]] | [[Category: Protein-rna complex]] | ||
[[Category: Rna binding protein]] | [[Category: Rna binding protein]] | ||
Current revision
Solution Structure of PHAX-RBD in complex with ssRNA
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