2xf1

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==CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM ACTIN DEPOLYMERIZATION FACTOR 1==
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<StructureSection load='2xf1' size='340' side='right' caption='[[2xf1]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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==Crystal structure of Plasmodium falciparum actin depolymerization factor 1==
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<StructureSection load='2xf1' size='340' side='right'caption='[[2xf1]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xf1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XF1 OCA]. <br>
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<table><tr><td colspan='2'>[[2xf1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XF1 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xf1 OCA], [https://pdbe.org/2xf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xf1 RCSB], [https://www.ebi.ac.uk/pdbsum/2xf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xf1 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xf1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xf1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xf1 PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/CADF1_PLAF7 CADF1_PLAF7] Not involved in actin polymerisation, instead functions to stimulate nucleotide exchange on monomeric actin and influence turnover of the small amount of cytosolic actin microfilaments. Essential for erythrocytic schizogony (By similarity).[UniProtKB:P86292]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite.,Singh BK, Sattler JM, Chatterjee M, Huttu J, Schuler H, Kursula I J Biol Chem. 2011 Aug 12;286(32):28256-64. PMID:21832095<ref>PMID:21832095</ref>
Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite.,Singh BK, Sattler JM, Chatterjee M, Huttu J, Schuler H, Kursula I J Biol Chem. 2011 Aug 12;286(32):28256-64. PMID:21832095<ref>PMID:21832095</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2xf1" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Chatterjee, M.]]
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[[Category: Chatterjee M]]
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[[Category: Huttu, J.]]
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[[Category: Huttu J]]
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[[Category: Kursula, I.]]
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[[Category: Kursula I]]
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[[Category: Sattler, J M.]]
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[[Category: Sattler JM]]
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[[Category: Schueler, H.]]
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[[Category: Schueler H]]
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[[Category: Singh, B K.]]
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[[Category: Singh BK]]
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[[Category: Actin-binding protein]]
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[[Category: Cytoskeleton]]
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Current revision

Crystal structure of Plasmodium falciparum actin depolymerization factor 1

PDB ID 2xf1

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