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2x9d

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==Tet repressor (class D) in complex with iso-7-chlortetracycline==
==Tet repressor (class D) in complex with iso-7-chlortetracycline==
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<StructureSection load='2x9d' size='340' side='right' caption='[[2x9d]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
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<StructureSection load='2x9d' size='340' side='right'caption='[[2x9d]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2x9d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1du7 1du7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9D OCA]. <br>
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<table><tr><td colspan='2'>[[2x9d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1du7 1du7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X9D FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ITC:ISO-7-CHLORTETRACYCLINE'>ITC</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xgc|2xgc]], [[2xpw|2xpw]], [[1bjz|1bjz]], [[2trt|2trt]], [[2xpv|2xpv]], [[2vkv|2vkv]], [[1ork|1ork]], [[2xge|2xge]], [[1a6i|1a6i]], [[2x6o|2x6o]], [[1qpi|1qpi]], [[2vke|2vke]], [[2xgd|2xgd]], [[2xrl|2xrl]], [[2xpt|2xpt]], [[2xpu|2xpu]], [[2xb5|2xb5]], [[1bj0|1bj0]], [[2xps|2xps]], [[1bjy|1bjy]], [[2tct|2tct]], [[1du7|1du7]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ITC:ISO-7-CHLORTETRACYCLINE'>ITC</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9d OCA], [https://pdbe.org/2x9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x9d RCSB], [https://www.ebi.ac.uk/pdbsum/2x9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x9d ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x9d RCSB], [http://www.ebi.ac.uk/pdbsum/2x9d PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Recognition of drug degradation products by target proteins: isotetracycline binding to Tet repressor.,Volkers G, Petruschka L, Hinrichs W J Med Chem. 2011 Jul 28;54(14):5108-15. Epub 2011 Jul 1. PMID:21699184<ref>PMID:21699184</ref>
Recognition of drug degradation products by target proteins: isotetracycline binding to Tet repressor.,Volkers G, Petruschka L, Hinrichs W J Med Chem. 2011 Jul 28;54(14):5108-15. Epub 2011 Jul 1. PMID:21699184<ref>PMID:21699184</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2x9d" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Hinrichs, W.]]
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[[Category: Large Structures]]
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[[Category: Volkers, G.]]
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[[Category: Hinrichs W]]
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[[Category: Antibiotic resistance]]
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[[Category: Volkers G]]
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[[Category: Dna-binding protein]]
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[[Category: Gene regulation]]
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[[Category: Hth-motif]]
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[[Category: Transcription]]
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Current revision

Tet repressor (class D) in complex with iso-7-chlortetracycline

PDB ID 2x9d

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