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2xvs

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==Crystal structure of human TTC5 (Strap) C-terminal OB domain==
==Crystal structure of human TTC5 (Strap) C-terminal OB domain==
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<StructureSection load='2xvs' size='340' side='right' caption='[[2xvs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='2xvs' size='340' side='right'caption='[[2xvs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. <br>
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<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVS FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [http://www.ebi.ac.uk/pdbsum/2xvs PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [https://pdbe.org/2xvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [https://www.ebi.ac.uk/pdbsum/2xvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvs ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TTC5_HUMAN TTC5_HUMAN] Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.,Adams CJ, Pike AC, Maniam S, Sharpe TD, Coutts AS, Knapp S, La Thangue NB, Bullock AN Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3778-83. Epub 2012 Feb 23. PMID:22362889<ref>PMID:22362889</ref>
The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.,Adams CJ, Pike AC, Maniam S, Sharpe TD, Coutts AS, Knapp S, La Thangue NB, Bullock AN Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3778-83. Epub 2012 Feb 23. PMID:22362889<ref>PMID:22362889</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2xvs" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Adams, J.]]
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[[Category: Large Structures]]
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[[Category: Bullock, A N.]]
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[[Category: Adams J]]
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[[Category: Coutts, A S.]]
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[[Category: Bullock AN]]
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[[Category: Knapp, S.]]
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[[Category: Coutts AS]]
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[[Category: Maniam, S.]]
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[[Category: Knapp S]]
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[[Category: Pike, A C.W.]]
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[[Category: La Thangue B]]
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[[Category: Sharpe, T D.]]
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[[Category: Maniam S]]
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[[Category: Thangue, B La.]]
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[[Category: Pike ACW]]
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[[Category: Antitumor protein]]
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[[Category: Sharpe TD]]
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[[Category: P300]]
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[[Category: P53 cofactor]]
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[[Category: Stress-response]]
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Current revision

Crystal structure of human TTC5 (Strap) C-terminal OB domain

PDB ID 2xvs

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