2y7e

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==CRYSTAL STRUCTURE OF THE 3-KETO-5-AMINOHEXANOATE CLEAVAGE ENZYME (KCE) FROM CANDIDATUS CLOACAMONAS ACIDAMINOVORANS (TETRAGONAL FORM)==
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<StructureSection load='2y7e' size='340' side='right' caption='[[2y7e]], [[Resolution|resolution]] 1.28&Aring;' scene=''>
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==Crystal structure of the 3-keto-5-aminohexanoate cleavage enzyme (Kce) from Candidatus Cloacamonas acidaminovorans (tetragonal form)==
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<StructureSection load='2y7e' size='340' side='right'caption='[[2y7e]], [[Resolution|resolution]] 1.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y7e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candidatus_cloacamonas_acidaminovorans Candidatus cloacamonas acidaminovorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7E OCA]. <br>
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<table><tr><td colspan='2'>[[2y7e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candidatus_Cloacimonas_acidaminovorans Candidatus Cloacimonas acidaminovorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y7E FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y7d|2y7d]], [[2y7g|2y7g]], [[2y7f|2y7f]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7e OCA], [https://pdbe.org/2y7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y7e RCSB], [https://www.ebi.ac.uk/pdbsum/2y7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y7e ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y7e RCSB], [http://www.ebi.ac.uk/pdbsum/2y7e PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCE_CLOAI KCE_CLOAI] Catalyzes the deprotonation of the beta-keto acid, nucleophilic addition onto acetyl-CoA, and intramolecular transfer of the CoA moiety to result in 3-aminobutanoyl-CoA and acetoacetate.<ref>PMID:21632536</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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3-keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.,Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M, Alzari PM J Biol Chem. 2011 Jun 1. PMID:21632536<ref>PMID:21632536</ref>
3-keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.,Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M, Alzari PM J Biol Chem. 2011 Jun 1. PMID:21632536<ref>PMID:21632536</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2y7e" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Candidatus cloacamonas acidaminovorans]]
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[[Category: Candidatus Cloacimonas acidaminovorans]]
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[[Category: Alzari, P M.]]
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[[Category: Large Structures]]
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[[Category: Bellinzoni, M.]]
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[[Category: Alzari PM]]
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[[Category: Aldolase]]
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[[Category: Bellinzoni M]]
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[[Category: Lyase]]
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Current revision

Crystal structure of the 3-keto-5-aminohexanoate cleavage enzyme (Kce) from Candidatus Cloacamonas acidaminovorans (tetragonal form)

PDB ID 2y7e

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