2yjy

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==A SPECIFIC AND MODULAR BINDING CODE FOR CYTOSINE RECOGNITION IN PUF DOMAINS==
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<StructureSection load='2yjy' size='340' side='right' caption='[[2yjy]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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==A specific and modular binding code for cytosine recognition in PUF domains==
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<StructureSection load='2yjy' size='340' side='right'caption='[[2yjy]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2yjy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJY OCA]. <br>
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<table><tr><td colspan='2'>[[2yjy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YJY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ib2|1ib2]], [[1m8y|1m8y]], [[1m8z|1m8z]], [[1m8w|1m8w]], [[1m8x|1m8x]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.598&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjy OCA], [https://pdbe.org/2yjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yjy RCSB], [https://www.ebi.ac.uk/pdbsum/2yjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjy ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yjy RCSB], [http://www.ebi.ac.uk/pdbsum/2yjy PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/PUM1_HUMAN PUM1_HUMAN] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Specific and Modular Binding Code for Cytosine Recognition in Pumilio/FBF (PUF) RNA-binding Domains.,Dong S, Wang Y, Cassidy-Amstutz C, Lu G, Bigler R, Jezyk MR, Li C, Hall TM, Wang Z J Biol Chem. 2011 Jul 29;286(30):26732-42. Epub 2011 Jun 8. PMID:21653694<ref>PMID:21653694</ref>
Specific and Modular Binding Code for Cytosine Recognition in Pumilio/FBF (PUF) RNA-binding Domains.,Dong S, Wang Y, Cassidy-Amstutz C, Lu G, Bigler R, Jezyk MR, Li C, Hall TM, Wang Z J Biol Chem. 2011 Jul 29;286(30):26732-42. Epub 2011 Jun 8. PMID:21653694<ref>PMID:21653694</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2yjy" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bigler, R.]]
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[[Category: Large Structures]]
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[[Category: Cassidy-Amstutz, C.]]
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[[Category: Synthetic construct]]
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[[Category: Dong, S.]]
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[[Category: Bigler R]]
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[[Category: Hall, T M.T.]]
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[[Category: Cassidy-Amstutz C]]
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[[Category: Jezyk, M.]]
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[[Category: Dong S]]
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[[Category: Li, C.]]
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[[Category: Hall TMT]]
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[[Category: Lu, G.]]
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[[Category: Jezyk M]]
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[[Category: Qiu, C.]]
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[[Category: Li C]]
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[[Category: Wang, Y.]]
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[[Category: Lu G]]
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[[Category: Wang, Z.]]
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[[Category: Qiu C]]
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[[Category: Nanos response element]]
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[[Category: Wang Y]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Wang Z]]

Current revision

A specific and modular binding code for cytosine recognition in PUF domains

PDB ID 2yjy

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