2ygk

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==Crystal structure of the NurA nuclease from Sulfolobus solfataricus==
==Crystal structure of the NurA nuclease from Sulfolobus solfataricus==
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<StructureSection load='2ygk' size='340' side='right' caption='[[2ygk]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='2ygk' size='340' side='right'caption='[[2ygk]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ygk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGK OCA]. <br>
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<table><tr><td colspan='2'>[[2ygk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YGK FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ygk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygk OCA], [https://pdbe.org/2ygk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ygk RCSB], [https://www.ebi.ac.uk/pdbsum/2ygk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ygk ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ygk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ygk RCSB], [http://www.ebi.ac.uk/pdbsum/2ygk PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/NURA_SACS2 NURA_SACS2] Involved in DNA double-strand break (DSB) repair (PubMed:22135300). Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Processes linear dsDNA probes with 3' or 5' single-stranded overhangs or blunt ends (PubMed:22135300).[UniProtKB:Q8U1N8]<ref>PMID:22135300</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complex.,Blackwood JK, Rzechorzek NJ, Abrams AS, Maman JD, Pellegrini L, Robinson NP Nucleic Acids Res. 2011 Dec 1. PMID:22135300<ref>PMID:22135300</ref>
Structural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complex.,Blackwood JK, Rzechorzek NJ, Abrams AS, Maman JD, Pellegrini L, Robinson NP Nucleic Acids Res. 2011 Dec 1. PMID:22135300<ref>PMID:22135300</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2ygk" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Sulfolobus solfataricus]]
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[[Category: Large Structures]]
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[[Category: Abrams, A S.]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Blackwood, J K.]]
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[[Category: Abrams AS]]
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[[Category: Maman, J D.]]
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[[Category: Blackwood JK]]
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[[Category: Pellegrini, L.]]
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[[Category: Maman JD]]
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[[Category: Robinson, N P.]]
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[[Category: Pellegrini L]]
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[[Category: Rzechorzek, N J.]]
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[[Category: Robinson NP]]
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[[Category: Dna repair]]
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[[Category: Rzechorzek NJ]]
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[[Category: Hydrolase]]
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[[Category: Replication]]
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Current revision

Crystal structure of the NurA nuclease from Sulfolobus solfataricus

PDB ID 2ygk

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