191d

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[[Image:191d.jpg|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF INTERCALATED FOUR-STRANDED D(C3T)==
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|PDB= 191d |SIZE=350|CAPTION= <scene name='initialview01'>191d</scene>, resolution 1.400&Aring;
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<StructureSection load='191d' size='340' side='right'caption='[[191d]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
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<table><tr><td colspan='2'>[[191d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=191D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=191D FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=191d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=191d OCA], [https://pdbe.org/191d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=191d RCSB], [https://www.ebi.ac.uk/pdbsum/191d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=191d ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE OF INTERCALATED FOUR-STRANDED D(C3T)'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Berger I]]
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The crystal structure of d(C3T), solved at 1.4 A resolution, reveals that the molecule forms a four-stranded intercalated complex. It consists of two parallel-stranded duplexes, each of which is held together by cytosine-protonated cytosine base pairs. The two duplexes are intercalated with each other and have opposite strand orientation. The molecule has a flat, lath-like appearance, and the covalently bonded cytosines have a slow right-handed twist of 17.1 degrees. However, there is considerable asymmetry. On one of the flat sides, the phosphate groups are rotated away from the center of the molecule. They are held in this orientation by bridging water molecules that bind the NH of cytosine and a phosphate group of an opposite chain. There is also considerable microheterogeneity in the structure. The cytosine hemiprotonation occurs even at pH 7 where stable crystals form.
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[[Category: Kang C]]
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[[Category: Lockshin C]]
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==About this Structure==
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[[Category: Moyzis R]]
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191D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=191D OCA].
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[[Category: Ratliff R]]
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[[Category: Rich A]]
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==Reference==
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Crystal structure of intercalated four-stranded d(C3T) at 1.4 A resolution., Kang CH, Berger I, Lockshin C, Ratliff R, Moyzis R, Rich A, Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11636-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7972115 7972115]
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[[Category: Protein complex]]
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[[Category: Berger, I.]]
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[[Category: Kang, C.]]
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[[Category: Lockshin, C.]]
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[[Category: Moyzis, R.]]
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[[Category: Ratliff, R.]]
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[[Category: Rich, A.]]
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[[Category: NA]]
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[[Category: base intercalated]]
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[[Category: mismatched]]
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[[Category: parallel-stranded tetraplex]]
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[[Category: quadruple helix]]
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[[Category: u-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:50:42 2008''
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Current revision

CRYSTAL STRUCTURE OF INTERCALATED FOUR-STRANDED D(C3T)

PDB ID 191d

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