3aty

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==Crystal structure of TcOYE==
==Crystal structure of TcOYE==
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<StructureSection load='3aty' size='340' side='right' caption='[[3aty]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3aty' size='340' side='right'caption='[[3aty]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3aty]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ATY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ATY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3aty]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ATY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ATY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3atz|3atz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TcPGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 Trypanosoma cruzi])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aty OCA], [https://pdbe.org/3aty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aty RCSB], [https://www.ebi.ac.uk/pdbsum/3aty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aty ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3aty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aty OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3aty RCSB], [http://www.ebi.ac.uk/pdbsum/3aty PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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<div style="background-color:#fffaf0;">
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[https://www.uniprot.org/uniprot/Q8I6L9_TRYCR Q8I6L9_TRYCR]
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== Publication Abstract from PubMed ==
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Old yellow enzyme (OYE) is an NADPH oxidoreductase capable of reducing a variety of compounds. It contains flavin mononucleotide (FMN) as a prosthetic group. A ternary complex structure of OYE from Trypanosoma cruzi (TcOYE) with FMN and one of the substrates, p-hydroxybenzaldehyde, shows a striking movement around the active site upon binding of the substrate. From a structural comparison of other OYE complexed with 12-oxophytodienoate, we have constructed a complex structure with another substrate, prostaglandin H(2) (PGH(2)), to provide a proposed stereoselective reaction mechanism for the reduction of PGH(2) to prostaglandin F(2alpha) by TcOYE.
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Structural insight into the stereoselective production of PGF2alpha by Old Yellow Enzyme from Trypanosoma cruzi.,Okamoto N, Yamaguchi K, Mizohata E, Tokuoka K, Uchiyama N, Sugiyama S, Matsumura H, Inaka K, Urade Y, Inoue T J Biochem. 2011 Nov;150(5):563-8. doi: 10.1093/jb/mvr096. Epub 2011 Aug, 12. PMID:21840922<ref>PMID:21840922</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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==See Also==
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</div>
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*[[NADPH dehydrogenase|NADPH dehydrogenase]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
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[[Category: Inaka, K.]]
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[[Category: Inaka K]]
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[[Category: Inoue, T.]]
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[[Category: Inoue T]]
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[[Category: Matsumura, H.]]
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[[Category: Matsumura H]]
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[[Category: Okamoto, N.]]
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[[Category: Okamoto N]]
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[[Category: Sugiyama, S.]]
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[[Category: Sugiyama S]]
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[[Category: Tokuoka, K.]]
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[[Category: Tokuoka K]]
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[[Category: Uchiyama, N.]]
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[[Category: Uchiyama N]]
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[[Category: Urade, Y.]]
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[[Category: Urade Y]]
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[[Category: Yamaguchi, K.]]
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[[Category: Yamaguchi K]]
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[[Category: Alpha/beta barrel]]
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[[Category: Flavin mononucleotide]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of TcOYE

PDB ID 3aty

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