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3w7n

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==Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-3-149==
==Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-3-149==
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<StructureSection load='3w7n' size='340' side='right' caption='[[3w7n]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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<StructureSection load='3w7n' size='340' side='right'caption='[[3w7n]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3w7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W7N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3w7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W7N FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=W7N:5-(2-{6-[(2-HYDROXYETHYL)CARBAMOYL]NAPHTHALEN-2-YL}ETHYL)-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W7N</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w1a|3w1a]], [[3w1l|3w1l]], [[3w1m|3w1m]], [[3w1n|3w1n]], [[3w1p|3w1p]], [[3w1q|3w1q]], [[3w1r|3w1r]], [[3w1t|3w1t]], [[3w1u|3w1u]], [[3w1x|3w1x]], [[3w22|3w22]], [[3w23|3w23]], [[3w2j|3w2j]], [[3w2k|3w2k]], [[3w2l|3w2l]], [[3w2m|3w2m]], [[3w2n|3w2n]], [[3w2u|3w2u]], [[4jd4|4jd4]], [[4jdb|4jdb]], [[3w6y|3w6y]], [[3w70|3w70]], [[3w71|3w71]], [[3w72|3w72]], [[3w73|3w73]], [[3w74|3w74]], [[3w75|3w75]], [[3w76|3w76]], [[3w7c|3w7c]], [[3w7d|3w7d]], [[3w7e|3w7e]], [[3w7g|3w7g]], [[3w7h|3w7h]], [[3w7i|3w7i]], [[3w7j|3w7j]], [[3w7k|3w7k]], [[3w7l|3w7l]], [[3w7m|3w7m]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=W7N:5-(2-{6-[(2-HYDROXYETHYL)CARBAMOYL]NAPHTHALEN-2-YL}ETHYL)-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W7N</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PyrD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w7n OCA], [https://pdbe.org/3w7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w7n RCSB], [https://www.ebi.ac.uk/pdbsum/3w7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w7n ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w7n RCSB], [http://www.ebi.ac.uk/pdbsum/3w7n PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
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==See Also==
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*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Trycc]]
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[[Category: Large Structures]]
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[[Category: Aoki, T.]]
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[[Category: Trypanosoma cruzi strain CL Brener]]
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[[Category: Balogun, E O.]]
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[[Category: Aoki T]]
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[[Category: Harada, S.]]
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[[Category: Balogun EO]]
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[[Category: Hashimoto, S.]]
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[[Category: Harada S]]
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[[Category: Honma, T.]]
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[[Category: Hashimoto S]]
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[[Category: Iida, M.]]
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[[Category: Honma T]]
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[[Category: Inaoka, D K.]]
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[[Category: Iida M]]
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[[Category: Inoue, M.]]
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[[Category: Inaoka DK]]
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[[Category: Kita, K.]]
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[[Category: Inoue M]]
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[[Category: Kuranaga, T.]]
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[[Category: Kita K]]
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[[Category: Lee, N.]]
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[[Category: Kuranaga T]]
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[[Category: Matsuoka, S.]]
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[[Category: Lee N]]
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[[Category: Nara, T.]]
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[[Category: Matsuoka S]]
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[[Category: Sakamoto, K.]]
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[[Category: Nara T]]
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[[Category: Shiba, T.]]
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[[Category: Sakamoto K]]
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[[Category: Suzuki, S.]]
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[[Category: Shiba T]]
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[[Category: Tabuchi, T.]]
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[[Category: Suzuki S]]
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[[Category: Tanaka, A.]]
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[[Category: Tabuchi T]]
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[[Category: Cytosol]]
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[[Category: Tanaka A]]
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[[Category: Dihydroorotate/orotate and fumarate/succinate binding]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Rossmann fold]]
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Current revision

Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with TT2-3-149

PDB ID 3w7n

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