3qsb
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Structure of E. coli polIIIbeta with (Z)-5-(1-((4'-Fluorobiphenyl-4-yl)methoxyimino)butyl)-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile== | ==Structure of E. coli polIIIbeta with (Z)-5-(1-((4'-Fluorobiphenyl-4-yl)methoxyimino)butyl)-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile== | ||
| - | <StructureSection load='3qsb' size='340' side='right' caption='[[3qsb]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='3qsb' size='340' side='right'caption='[[3qsb]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3qsb]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3qsb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QSB FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=743:(1R,5R)-5-{(1Z)-N-[(4-FLUOROBIPHENYL-4-YL)METHOXY]BUTANIMIDOYL}-2,2-DIMETHYL-4,6-DIOXOCYCLOHEXANECARBONITRILE'>743</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=743:(1R,5R)-5-{(1Z)-N-[(4-FLUOROBIPHENYL-4-YL)METHOXY]BUTANIMIDOYL}-2,2-DIMETHYL-4,6-DIOXOCYCLOHEXANECARBONITRILE'>743</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qsb OCA], [https://pdbe.org/3qsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qsb RCSB], [https://www.ebi.ac.uk/pdbsum/3qsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qsb ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA. | |
| - | <table> | + | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 16: | Line 16: | ||
Binding Inhibitors of the Bacterial Sliding Clamp by Design.,Wijffels G, Johnson WM, Oakley AJ, Turner K, Epa VC, Briscoe SJ, Polley M, Liepa AJ, Hofmann A, Buchardt J, Christensen C, Prosselkov P, Dalrymple BP, Alewood PF, Jennings PA, Dixon NE, Winkler DA J Med Chem. 2011 May 23. PMID:21604761<ref>PMID:21604761</ref> | Binding Inhibitors of the Bacterial Sliding Clamp by Design.,Wijffels G, Johnson WM, Oakley AJ, Turner K, Epa VC, Briscoe SJ, Polley M, Liepa AJ, Hofmann A, Buchardt J, Christensen C, Prosselkov P, Dalrymple BP, Alewood PF, Jennings PA, Dixon NE, Winkler DA J Med Chem. 2011 May 23. PMID:21604761<ref>PMID:21604761</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 3qsb" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Alewood | + | [[Category: Alewood PF]] |
| - | [[Category: Briscoe | + | [[Category: Briscoe SJ]] |
| - | [[Category: Buchardt | + | [[Category: Buchardt J]] |
| - | [[Category: Christensen | + | [[Category: Christensen C]] |
| - | [[Category: Dalrymple | + | [[Category: Dalrymple BP]] |
| - | [[Category: Dixon | + | [[Category: Dixon NE]] |
| - | [[Category: Epa | + | [[Category: Epa VC]] |
| - | [[Category: Hofmann | + | [[Category: Hofmann A]] |
| - | [[Category: Jennings | + | [[Category: Jennings PA]] |
| - | [[Category: Johnson | + | [[Category: Johnson WM]] |
| - | [[Category: Liepa | + | [[Category: Liepa AJ]] |
| - | [[Category: Oakley | + | [[Category: Oakley AJ]] |
| - | [[Category: Polley | + | [[Category: Polley M]] |
| - | [[Category: Prosselkov | + | [[Category: Prosselkov P]] |
| - | [[Category: Turner | + | [[Category: Turner K]] |
| - | [[Category: Wijffels | + | [[Category: Wijffels G]] |
| - | [[Category: Winkler | + | [[Category: Winkler DA]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structure of E. coli polIIIbeta with (Z)-5-(1-((4'-Fluorobiphenyl-4-yl)methoxyimino)butyl)-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile
| |||||||||||
Categories: Escherichia coli K-12 | Large Structures | Alewood PF | Briscoe SJ | Buchardt J | Christensen C | Dalrymple BP | Dixon NE | Epa VC | Hofmann A | Jennings PA | Johnson WM | Liepa AJ | Oakley AJ | Polley M | Prosselkov P | Turner K | Wijffels G | Winkler DA
