3ufa

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==Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor==
==Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor==
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<StructureSection load='3ufa' size='340' side='right' caption='[[3ufa]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3ufa' size='340' side='right'caption='[[3ufa]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ufa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UFA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ufa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UFA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=VPF:N-(3-CARBOXYPROPANOYL)-L-VALYL-N-[(1S)-2-PHENYL-1-PHOSPHONOETHYL]-L-PROLINAMIDE'>VPF</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">splA, SAOUHSC_01942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93061 STAA8])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=VPF:N-(3-CARBOXYPROPANOYL)-L-VALYL-N-[(1S)-2-PHENYL-1-PHOSPHONOETHYL]-L-PROLINAMIDE'>VPF</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ufa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ufa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ufa RCSB], [http://www.ebi.ac.uk/pdbsum/3ufa PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ufa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ufa OCA], [https://pdbe.org/3ufa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ufa RCSB], [https://www.ebi.ac.uk/pdbsum/3ufa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ufa ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPLA_STAA8 SPLA_STAA8]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.,Burchacka E, Zdzalik M, Niemczyk JS, Pustelny K, Popowicz G, Wladyka B, Dubin A, Potempa J, Sienczyk M, Dubin G, Oleksyszyn J Protein Sci. 2013 Dec 4. doi: 10.1002/pro.2403. PMID:24375505<ref>PMID:24375505</ref>
Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.,Burchacka E, Zdzalik M, Niemczyk JS, Pustelny K, Popowicz G, Wladyka B, Dubin A, Potempa J, Sienczyk M, Dubin G, Oleksyszyn J Protein Sci. 2013 Dec 4. doi: 10.1002/pro.2403. PMID:24375505<ref>PMID:24375505</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3ufa" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Staa8]]
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[[Category: Large Structures]]
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[[Category: Dubin, G.]]
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[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
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[[Category: Oleksyszyn, J.]]
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[[Category: Dubin G]]
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[[Category: Pietrusewicz, E.]]
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[[Category: Oleksyszyn J]]
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[[Category: Popowicz, G M.]]
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[[Category: Pietrusewicz E]]
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[[Category: Potempa, J.]]
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[[Category: Popowicz GM]]
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[[Category: Pustelny, K.]]
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[[Category: Potempa J]]
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[[Category: Stec-Niemczyk, J.]]
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[[Category: Pustelny K]]
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[[Category: Zdzalik, M.]]
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[[Category: Stec-Niemczyk J]]
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[[Category: Chymotrypsin like fold]]
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[[Category: Zdzalik M]]
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[[Category: Extracellular protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Serine protease]]
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Current revision

Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor

PDB ID 3ufa

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