4ixj

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==The structure of PilJ, a Type IV pilin from Clostridium difficile==
==The structure of PilJ, a Type IV pilin from Clostridium difficile==
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<StructureSection load='4ixj' size='340' side='right' caption='[[4ixj]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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<StructureSection load='4ixj' size='340' side='right'caption='[[4ixj]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ixj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_difficilis"_hall_and_o'toole_1935 "bacillus difficilis" hall and o'toole 1935]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IXJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ixj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile Clostridioides difficile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IXJ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.983&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1oqv|1oqv]], [[3sot|3sot]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDR20291_0683 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1496 "Bacillus difficilis" Hall and O'Toole 1935])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ixj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixj OCA], [https://pdbe.org/4ixj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ixj RCSB], [https://www.ebi.ac.uk/pdbsum/4ixj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixj ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ixj RCSB], [http://www.ebi.ac.uk/pdbsum/4ixj PDBsum]</span></td></tr>
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</table>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Type IV pili are produced by many pathogenic Gram-negative bacteria and are important for processes as diverse as twitching motility, cellular adhesion and colonization. Recently, there has been an increased appreciation of the ability of Gram-positive species, including C. difficile, to produce Type IV pili. Here we report the first three-dimensional structure of a Gram-positive Type IV pilin, PilJ, demonstrate its incorporation into Type IV pili and offer insights into how the Type IV pili of C. difficile may assemble and function. PilJ has several unique structural features, including a dual-pilin fold and the incorporation of a structural zinc ion. We show that PilJ is incorporated into Type IV pili in C. difficile and present a model in which the incorporation of PilJ into pili exposes the C-terminal domain of PilJ to create a novel interaction surface.
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Structure of Clostridium difficile PilJ Exhibits Unprecedented Divergence from Known Type IV Pilins.,Piepenbrink KH, Maldarelli GA, Martinez de la Pena CF, Mulvey GL, Snyder GA, De Masi L, von Rosenvinge EC, Guenther S, Armstrong GD, Donnenberg MS, Sundberg EJ J Biol Chem. 2013 Dec 21. PMID:24362261<ref>PMID:24362261</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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==See Also==
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</div>
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*[[Pilin 3D structures|Pilin 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus difficilis hall and o'toole 1935]]
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[[Category: Clostridioides difficile]]
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[[Category: Piepenbrink, K H.]]
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[[Category: Large Structures]]
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[[Category: Snyder, G A.]]
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[[Category: Piepenbrink KH]]
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[[Category: Sundberg, E J.]]
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[[Category: Snyder GA]]
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[[Category: Cell adhesion]]
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[[Category: Sundberg EJ]]
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[[Category: Filament formation]]
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Current revision

The structure of PilJ, a Type IV pilin from Clostridium difficile

PDB ID 4ixj

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