This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4lqk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:19, 14 December 2022) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Structure of the vaccinia virus NF- B antagonist A46==
==Structure of the vaccinia virus NF- B antagonist A46==
-
<StructureSection load='4lqk' size='340' side='right' caption='[[4lqk]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
+
<StructureSection load='4lqk' size='340' side='right'caption='[[4lqk]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4lqk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccw Vaccw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LQK FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4lqk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_WR Vaccinia virus WR]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LQK FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lqk OCA], [https://pdbe.org/4lqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lqk RCSB], [https://www.ebi.ac.uk/pdbsum/4lqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lqk ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VACWR172, A46R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10254 VACCW])</td></tr>
+
</table>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lqk RCSB], [http://www.ebi.ac.uk/pdbsum/4lqk PDBsum]</span></td></tr>
+
== Function ==
-
<table>
+
[https://www.uniprot.org/uniprot/A46_VACCW A46_VACCW] Bcl-2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Targets several host TIR adapters including MYD88, TIRAP, TRIF and TICAM2 thereby blocking NF-kappa-B and TRIF-mediated IRF3 activation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 14: Line 15:
Characterization and structure of the vaccinia virus NF-kappaB antagonist A46.,Fedosyuk S, Grishkovskaya I, de Almeida Ribeiro E Jr, Skern T J Biol Chem. 2014 Feb 7;289(6):3749-62. doi: 10.1074/jbc.M113.512756. Epub 2013, Dec 19. PMID:24356965<ref>PMID:24356965</ref>
Characterization and structure of the vaccinia virus NF-kappaB antagonist A46.,Fedosyuk S, Grishkovskaya I, de Almeida Ribeiro E Jr, Skern T J Biol Chem. 2014 Feb 7;289(6):3749-62. doi: 10.1074/jbc.M113.512756. Epub 2013, Dec 19. PMID:24356965<ref>PMID:24356965</ref>
-
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4lqk" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Vaccw]]
+
[[Category: Large Structures]]
-
[[Category: Djinovic-Carugo, K.]]
+
[[Category: Vaccinia virus WR]]
-
[[Category: Fedosyuk, S.]]
+
[[Category: Djinovic-Carugo K]]
-
[[Category: Grishkovskaya, I.]]
+
[[Category: Fedosyuk S]]
-
[[Category: Skern, T.]]
+
[[Category: Grishkovskaya I]]
-
[[Category: Bcl-2-like fold]]
+
[[Category: Skern T]]
-
[[Category: Viral protein]]
+

Current revision

Structure of the vaccinia virus NF- B antagonist A46

PDB ID 4lqk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4lqk"
Personal tools