4mvn

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==Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor==
==Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor==
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<StructureSection load='4mvn' size='340' side='right' caption='[[4mvn]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4mvn' size='340' side='right'caption='[[4mvn]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mvn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MVN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mvn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MVN FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I1S:[(1S)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-PHENYLETHYL]PHOSPHONIC+ACID'>I1S</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ufa|3ufa]], [[3w7s|3w7s]], [[2w7u|2w7u]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I1S:[(1S)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-PHENYLETHYL]PHOSPHONIC+ACID'>I1S</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPLA, SAOUHSC_01942 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93061 STAA8])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvn OCA], [https://pdbe.org/4mvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mvn RCSB], [https://www.ebi.ac.uk/pdbsum/4mvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mvn ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mvn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mvn RCSB], [http://www.ebi.ac.uk/pdbsum/4mvn PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPLA_STAA8 SPLA_STAA8]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.,Burchacka E, Zdzalik M, Niemczyk JS, Pustelny K, Popowicz G, Wladyka B, Dubin A, Potempa J, Sienczyk M, Dubin G, Oleksyszyn J Protein Sci. 2013 Dec 4. doi: 10.1002/pro.2403. PMID:24375505<ref>PMID:24375505</ref>
Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.,Burchacka E, Zdzalik M, Niemczyk JS, Pustelny K, Popowicz G, Wladyka B, Dubin A, Potempa J, Sienczyk M, Dubin G, Oleksyszyn J Protein Sci. 2013 Dec 4. doi: 10.1002/pro.2403. PMID:24375505<ref>PMID:24375505</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4mvn" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Staa8]]
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[[Category: Large Structures]]
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[[Category: Burchacka, E.]]
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[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
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[[Category: Dubin, A.]]
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[[Category: Burchacka E]]
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[[Category: Dubin, G.]]
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[[Category: Dubin A]]
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[[Category: Niemczyk, J S.]]
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[[Category: Dubin G]]
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[[Category: Oleksyszyn, J.]]
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[[Category: Niemczyk JS]]
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[[Category: Popowicz, G M.]]
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[[Category: Oleksyszyn J]]
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[[Category: Potempa, J.]]
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[[Category: Popowicz GM]]
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[[Category: Pustelny, K.]]
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[[Category: Potempa J]]
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[[Category: Sienczyk, M.]]
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[[Category: Pustelny K]]
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[[Category: Wladyka, B.]]
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[[Category: Sienczyk M]]
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[[Category: Zdzalik, M.]]
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[[Category: Wladyka B]]
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[[Category: Chymotrypsin-like fold]]
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[[Category: Zdzalik M]]
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[[Category: Extracellular staphylococcal protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Serine endopeptidase]]
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Current revision

Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor

PDB ID 4mvn

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