4p6i

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==Crystal structure of the Cas1-Cas2 complex from Escherichia coli==
==Crystal structure of the Cas1-Cas2 complex from Escherichia coli==
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<StructureSection load='4p6i' size='340' side='right' caption='[[4p6i]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4p6i' size='340' side='right'caption='[[4p6i]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4p6i]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P6I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4p6i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. The January 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Cascade and CRISPR'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_1 10.2210/rcsb_pdb/mom_2015_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P6I FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p6i RCSB], [http://www.ebi.ac.uk/pdbsum/4p6i PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6i OCA], [https://pdbe.org/4p6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p6i RCSB], [https://www.ebi.ac.uk/pdbsum/4p6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p6i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAS2_ECOLI CAS2_ECOLI] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).<ref>PMID:21255106</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity.,Nunez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA Nat Struct Mol Biol. 2014 May 4. doi: 10.1038/nsmb.2820. PMID:24793649<ref>PMID:24793649</ref>
Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity.,Nunez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA Nat Struct Mol Biol. 2014 May 4. doi: 10.1038/nsmb.2820. PMID:24793649<ref>PMID:24793649</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4p6i" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Doudna, J A.]]
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[[Category: Cascade and CRISPR]]
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[[Category: Kranzusch, P J.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Noeske, J.]]
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[[Category: Large Structures]]
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[[Category: Nunez, J K.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Crispr-associated protein]]
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[[Category: Doudna JA]]
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[[Category: Hydrolase]]
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[[Category: Kranzusch PJ]]
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[[Category: Nuclease]]
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[[Category: Noeske J]]
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[[Category: Nunez JK]]

Current revision

Crystal structure of the Cas1-Cas2 complex from Escherichia coli

PDB ID 4p6i

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