4ox9

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==Crystal structure of the aminoglycoside resistance methyltransferase NpmA bound to the 30S ribosomal subunit==
==Crystal structure of the aminoglycoside resistance methyltransferase NpmA bound to the 30S ribosomal subunit==
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<StructureSection load='4ox9' size='340' side='right' caption='[[4ox9]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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<StructureSection load='4ox9' size='340' side='right'caption='[[4ox9]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ox9]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OX9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ox9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] and [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OX9 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8035&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">npmA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/16S_rRNA_(adenine(1408)-N(1))-methyltransferase 16S rRNA (adenine(1408)-N(1))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.180 2.1.1.180] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ox9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ox9 OCA], [https://pdbe.org/4ox9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ox9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ox9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ox9 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ox9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ox9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ox9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ox9 PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/RS4_THET8 RS4_THET8] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the body and platform of the 30S subunit. Binds mRNA in the 70S ribosome, positioning it for translation.[HAMAP-Rule:MF_01306_B]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA.,Dunkle JA, Vinal K, Desai PM, Zelinskaya N, Savic M, West DM, Conn GL, Dunham CM Proc Natl Acad Sci U S A. 2014 Apr 9. PMID:24717845<ref>PMID:24717845</ref>
Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA.,Dunkle JA, Vinal K, Desai PM, Zelinskaya N, Savic M, West DM, Conn GL, Dunham CM Proc Natl Acad Sci U S A. 2014 Apr 9. PMID:24717845<ref>PMID:24717845</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4ox9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ribosomal protein THX 3D structures|Ribosomal protein THX 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Conn, G L.]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Dunham, C M.]]
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[[Category: Conn GL]]
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[[Category: Dunkle, J A.]]
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[[Category: Dunham CM]]
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[[Category: 16]]
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[[Category: Dunkle JA]]
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[[Category: 30]]
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[[Category: A1408]]
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[[Category: Aminoglycoside]]
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[[Category: Methyltransferase]]
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[[Category: Protein biosynthesis]]
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[[Category: Ribosomal subunit]]
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[[Category: Ribosome]]
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[[Category: Ribosome-antibiotic complex]]
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[[Category: Rna]]
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Current revision

Crystal structure of the aminoglycoside resistance methyltransferase NpmA bound to the 30S ribosomal subunit

PDB ID 4ox9

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