4nwr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Computationally Designed Two-Component Self-Assembling Tetrahedral Cage T33-28== | |
| + | <StructureSection load='4nwr' size='340' side='right'caption='[[4nwr]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4nwr]] is a 96 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major] and [https://en.wikipedia.org/wiki/Uncultured_bacterium Uncultured bacterium]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vw5 1vw5] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vw6 1vw6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NWR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwr OCA], [https://pdbe.org/4nwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nwr RCSB], [https://www.ebi.ac.uk/pdbsum/4nwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B0BGB0_9BACT B0BGB0_9BACT] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The self-assembly of proteins into highly ordered nanoscale architectures is a hallmark of biological systems. The sophisticated functions of these molecular machines have inspired the development of methods to engineer self-assembling protein nanostructures; however, the design of multi-component protein nanomaterials with high accuracy remains an outstanding challenge. Here we report a computational method for designing protein nanomaterials in which multiple copies of two distinct subunits co-assemble into a specific architecture. We use the method to design five 24-subunit cage-like protein nanomaterials in two distinct symmetric architectures and experimentally demonstrate that their structures are in close agreement with the computational design models. The accuracy of the method and the number and variety of two-component materials that it makes accessible suggest a route to the construction of functional protein nanomaterials tailored to specific applications. | ||
| - | + | Accurate design of co-assembling multi-component protein nanomaterials.,King NP, Bale JB, Sheffler W, McNamara DE, Gonen S, Gonen T, Yeates TO, Baker D Nature. 2014 Jun 5;510(7503):103-8. doi: 10.1038/nature13404. Epub 2014 May 25. PMID:24870237<ref>PMID:24870237</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4nwr" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Macrophage inhibitory factor 3D structures|Macrophage inhibitory factor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Leishmania major]] | ||
| + | [[Category: Uncultured bacterium]] | ||
| + | [[Category: Baker D]] | ||
| + | [[Category: Bale JB]] | ||
| + | [[Category: King NP]] | ||
| + | [[Category: McNamara DE]] | ||
| + | [[Category: Sheffler W]] | ||
| + | [[Category: Yeates TO]] | ||
Current revision
Computationally Designed Two-Component Self-Assembling Tetrahedral Cage T33-28
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