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3wae

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==X-ray structure of Fe(III)-bicarbonates-ttfbpa, a ferric ion-binding protein from thermus thermophilus HB8==
==X-ray structure of Fe(III)-bicarbonates-ttfbpa, a ferric ion-binding protein from thermus thermophilus HB8==
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<StructureSection load='3wae' size='340' side='right' caption='[[3wae]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3wae' size='340' side='right'caption='[[3wae]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wae]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WAE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wae]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WAE FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3waf|3waf]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wae OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wae RCSB], [http://www.ebi.ac.uk/pdbsum/3wae PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wae OCA], [https://pdbe.org/3wae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wae RCSB], [https://www.ebi.ac.uk/pdbsum/3wae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wae ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q5SHV2_THET8 Q5SHV2_THET8]
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Crystal structures of FbpA, the periplasmic ferric ion-binding protein of an iron-uptake ABC transporter, from Thermus thermophilus HB8 (TtFbpA) have been solved in apo and ferric ion-bound forms at 1.8 and 1.7 A resolution, respectively. The latter crystal structure shows that the bound ferric ion forms a novel six-coordinated complex with three tyrosine side chains, two bicarbonates and a water molecule in the metal-binding site. The results of gel-filtration chromatography and dynamic light scattering show that TtFbpA exists as a monomer in solution regardless of ferric ion binding and that TtFbpA adopts a more compact conformation in the ferric ion-bound state than in the apo state in solution.
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A novel mode of ferric ion coordination by the periplasmic ferric ion-binding subunit FbpA of an ABC-type iron transporter from Thermus thermophilus HB8.,Wang S, Ogata M, Horita S, Ohtsuka J, Nagata K, Tanokura M Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):196-202. doi:, 10.1107/S1399004713026333. Epub 2013 Dec 31. PMID:24419392<ref>PMID:24419392</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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==See Also==
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</div>
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*[[ABC transporter 3D structures|ABC transporter 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Horita, S.]]
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[[Category: Large Structures]]
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[[Category: Nagata, K.]]
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[[Category: Thermus thermophilus]]
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[[Category: Ogata, M.]]
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[[Category: Horita S]]
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[[Category: Ohtsuka, J.]]
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[[Category: Nagata K]]
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[[Category: Tanokura, M.]]
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[[Category: Ogata M]]
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[[Category: Wang, S.]]
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[[Category: Ohtsuka J]]
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[[Category: A ferric binding protein]]
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[[Category: Tanokura M]]
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[[Category: Ferric ion]]
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[[Category: Wang S]]
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[[Category: Metal binding protein]]
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Current revision

X-ray structure of Fe(III)-bicarbonates-ttfbpa, a ferric ion-binding protein from thermus thermophilus HB8

PDB ID 3wae

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