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3lrg

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==Structure of anti-huntingtin VL domain==
==Structure of anti-huntingtin VL domain==
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<StructureSection load='3lrg' size='340' side='right' caption='[[3lrg]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='3lrg' size='340' side='right'caption='[[3lrg]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lrg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LRG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lrg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LRG FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lrh|3lrh]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VL12.3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrg OCA], [https://pdbe.org/3lrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lrg RCSB], [https://www.ebi.ac.uk/pdbsum/3lrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lrg ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lrg RCSB], [http://www.ebi.ac.uk/pdbsum/3lrg PDBsum]</span></td></tr>
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</table>
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<table>
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<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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A Disulfide-Free Single-Domain V(L) Intrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition.,Schiefner A, Chatwell L, Korner J, Neumaier I, Colby DW, Volkmer R, Wittrup KD, Skerra A J Mol Biol. 2011 Sep 24. PMID:21968397<ref>PMID:21968397</ref>
A Disulfide-Free Single-Domain V(L) Intrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition.,Schiefner A, Chatwell L, Korner J, Neumaier I, Colby DW, Volkmer R, Wittrup KD, Skerra A J Mol Biol. 2011 Sep 24. PMID:21968397<ref>PMID:21968397</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3lrg" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chatwell, L.]]
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[[Category: Large Structures]]
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[[Category: Schiefner, A.]]
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[[Category: Chatwell L]]
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[[Category: Skerra, A.]]
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[[Category: Schiefner A]]
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[[Category: Huntingtin]]
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[[Category: Skerra A]]
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[[Category: Huntington's disease]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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[[Category: Intrabody]]
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[[Category: Variable light chain domain]]
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Current revision

Structure of anti-huntingtin VL domain

PDB ID 3lrg

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