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3l9l
From Proteopedia
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==Crystal structure of pka with compound 36== | ==Crystal structure of pka with compound 36== | ||
| - | <StructureSection load='3l9l' size='340' side='right' caption='[[3l9l]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='3l9l' size='340' side='right'caption='[[3l9l]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3l9l]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3l9l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L9L FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L9L:5-[2-({(2S)-2-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPYL}AMINO)-1,3-THIAZOL-5-YL]-1,3-DIHYDRO-2H-INDOL-2-ONE'>L9L</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L9L:5-[2-({(2S)-2-AMINO-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPYL}AMINO)-1,3-THIAZOL-5-YL]-1,3-DIHYDRO-2H-INDOL-2-ONE'>L9L</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l9l OCA], [https://pdbe.org/3l9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l9l RCSB], [https://www.ebi.ac.uk/pdbsum/3l9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l9l ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. | |
| - | <table> | + | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Azole-based inhibitors of AKT/PKB for the treatment of cancer.,Zeng Q, Allen JG, Bourbeau MP, Wang X, Yao G, Tadesse S, Rider JT, Yuan CC, Hong FT, Lee MR, Zhang S, Lofgren JA, Freeman DJ, Yang S, Li C, Tominey E, Huang X, Hoffman D, Yamane HK, Fotsch C, Dominguez C, Hungate R, Zhang X Bioorg Med Chem Lett. 2010 Mar 1;20(5):1559-64. Epub 2010 Jan 21. PMID:20137943<ref>PMID:20137943</ref> | Azole-based inhibitors of AKT/PKB for the treatment of cancer.,Zeng Q, Allen JG, Bourbeau MP, Wang X, Yao G, Tadesse S, Rider JT, Yuan CC, Hong FT, Lee MR, Zhang S, Lofgren JA, Freeman DJ, Yang S, Li C, Tominey E, Huang X, Hoffman D, Yamane HK, Fotsch C, Dominguez C, Hungate R, Zhang X Bioorg Med Chem Lett. 2010 Mar 1;20(5):1559-64. Epub 2010 Jan 21. PMID:20137943<ref>PMID:20137943</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 3l9l" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Huang | + | [[Category: Huang X]] |
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Current revision
Crystal structure of pka with compound 36
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