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1aei

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[[Image:1aei.jpg|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER==
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|PDB= 1aei |SIZE=350|CAPTION= <scene name='initialview01'>1aei</scene>, resolution 2.8&Aring;
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<StructureSection load='1aei' size='340' side='right'caption='[[1aei]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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<table><tr><td colspan='2'>[[1aei]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AEI FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aei OCA], [https://pdbe.org/1aei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aei RCSB], [https://www.ebi.ac.uk/pdbsum/1aei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aei ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ANX12_HYDVU ANX12_HYDVU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/1aei_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1aei ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER'''
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==See Also==
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*[[Annexin 3D structures|Annexin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Annexins are a family of calcium- and phospholipid-binding proteins implicated in a number of biological processes including membrane fusion and ion channel formation. The crystal structure of the annexin XII hexamer, refined at 2.8 A resolution, forms a concave disk with 3-2 symmetry, about 100 A in diameter and 70 A thick with a central hydrophilic pore. Six intermolecular Ca2+ ions are involved in hexamer formation. An additional 18 Ca2+ ions are located on the perimeter of the disk, accessible only from the side of the hexameric disk. On the basis of the hexamer structure we propose here a new mode of protein-phospholipid bilayer interaction that is distinct from the hydrophobic insertion of typical membrane proteins. This speculative model postulates the Ca(2+)-dependent insertion of the hydrophilic annexin XII hexamer into phospholipid bilayers with local reorientation of the bilayer phospholipids.
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==About this Structure==
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1AEI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AEI OCA].
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==Reference==
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Crystal structure of the annexin XII hexamer and implications for bilayer insertion., Luecke H, Chang BT, Mailliard WS, Schlaepfer DD, Haigler HT, Nature. 1995 Nov 30;378(6556):512-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7477411 7477411]
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[[Category: Hydra vulgaris]]
[[Category: Hydra vulgaris]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chang, B T.]]
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[[Category: Chang BT]]
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[[Category: Haigler, H T.]]
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[[Category: Haigler HT]]
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[[Category: Luecke, H.]]
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[[Category: Luecke H]]
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[[Category: Mailliard, W S.]]
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[[Category: Mailliard WS]]
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[[Category: Schlaepfer, D D.]]
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[[Category: Schlaepfer DD]]
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[[Category: CA]]
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[[Category: annexin]]
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[[Category: calcium]]
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[[Category: calcium/phospholipid-binding]]
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[[Category: phospholipid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:56:23 2008''
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Current revision

CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER

PDB ID 1aei

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