This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3lrh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:42, 6 September 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Structure of anti-huntingtin VL domain in complex with huntingtin peptide==
==Structure of anti-huntingtin VL domain in complex with huntingtin peptide==
-
<StructureSection load='3lrh' size='340' side='right' caption='[[3lrh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+
<StructureSection load='3lrh' size='340' side='right'caption='[[3lrh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3lrh]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LRH FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3lrh]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LRH FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lrg|3lrg]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VL12.3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrh OCA], [https://pdbe.org/3lrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lrh RCSB], [https://www.ebi.ac.uk/pdbsum/3lrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lrh ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lrh RCSB], [http://www.ebi.ac.uk/pdbsum/3lrh PDBsum]</span></td></tr>
+
</table>
-
<table>
+
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/HD_HUMAN HD_HUMAN]] Juvenile Huntington disease;Huntington disease. The disease is caused by mutations affecting the gene represented in this entry.
+
[https://www.uniprot.org/uniprot/HD_HUMAN HD_HUMAN] Juvenile Huntington disease;Huntington disease. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/HD_HUMAN HD_HUMAN]] May play a role in microtubule-mediated transport or vesicle function.
+
[https://www.uniprot.org/uniprot/HD_HUMAN HD_HUMAN] May play a role in microtubule-mediated transport or vesicle function.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 17: Line 17:
A Disulfide-Free Single-Domain V(L) Intrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition.,Schiefner A, Chatwell L, Korner J, Neumaier I, Colby DW, Volkmer R, Wittrup KD, Skerra A J Mol Biol. 2011 Sep 24. PMID:21968397<ref>PMID:21968397</ref>
A Disulfide-Free Single-Domain V(L) Intrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition.,Schiefner A, Chatwell L, Korner J, Neumaier I, Colby DW, Volkmer R, Wittrup KD, Skerra A J Mol Biol. 2011 Sep 24. PMID:21968397<ref>PMID:21968397</ref>
-
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3lrh" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
Line 24: Line 25:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Chatwell, L.]]
+
[[Category: Large Structures]]
-
[[Category: Schiefner, A.]]
+
[[Category: Chatwell L]]
-
[[Category: Skerra, A.]]
+
[[Category: Schiefner A]]
-
[[Category: Huntingtin]]
+
[[Category: Skerra A]]
-
[[Category: Huntington's disease]]
+
-
[[Category: Immune system]]
+
-
[[Category: Immunoglobulin]]
+
-
[[Category: Intrabody]]
+
-
[[Category: Variable light chain domain]]
+

Current revision

Structure of anti-huntingtin VL domain in complex with huntingtin peptide

PDB ID 3lrh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3lrh"
Personal tools