1af0

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[[Image:1af0.gif|left|200px]]
 
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{{Structure
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==SERRATIA PROTEASE IN COMPLEX WITH INHIBITOR==
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|PDB= 1af0 |SIZE=350|CAPTION= <scene name='initialview01'>1af0</scene>, resolution 1.80&Aring;
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<StructureSection load='1af0' size='340' side='right'caption='[[1af0]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE= <scene name='pdbsite=ACT:Active+Site,+Histidines+Are+Zn+Ligands+And+E+177+The+Put+...'>ACT</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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<table><tr><td colspan='2'>[[1af0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AF0 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Serralysin Serralysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.40 3.4.24.40]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Z9:N-[(BENZYLOXY)CARBONYL]-L-LEUCYL-N-HYDROXY-L-ALANINAMIDE'>0Z9</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1af0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1af0 OCA], [https://pdbe.org/1af0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1af0 RCSB], [https://www.ebi.ac.uk/pdbsum/1af0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1af0 ProSAT]</span></td></tr>
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</table>
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'''SERRATIA PROTEASE IN COMPLEX WITH INHIBITOR'''
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== Function ==
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[https://www.uniprot.org/uniprot/PRZN_SERMA PRZN_SERMA] Has insecticidal activity against the locust M.palpalis. When administered orally to locusts at a low dose it causes them to lie on their sides exhibiting sporadic limb movements and muscular twitching, followed by full recovery. When administered at higher doses the same symptoms are observed, followed by death.
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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1AF0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AF0 OCA].
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Check<jmol>
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[[Category: Serralysin]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/1af0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1af0 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Serratia marcescens]]
[[Category: Serratia marcescens]]
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[[Category: Single protein]]
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[[Category: Baumann U]]
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[[Category: Baumann, U.]]
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[[Category: CA]]
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[[Category: ZN]]
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[[Category: complex (metalloprotease/inhibitor)]]
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[[Category: hydrolase]]
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[[Category: metalloprotease]]
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[[Category: serralysin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:56:37 2008''
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Current revision

SERRATIA PROTEASE IN COMPLEX WITH INHIBITOR

PDB ID 1af0

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