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4pdp

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==Crystal structure of Rad53 kinase domain and SCD2==
==Crystal structure of Rad53 kinase domain and SCD2==
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<StructureSection load='4pdp' size='340' side='right' caption='[[4pdp]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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<StructureSection load='4pdp' size='340' side='right'caption='[[4pdp]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pdp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PDP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PDP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pdp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PDP FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pds|4pds]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.591&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pdp OCA], [https://pdbe.org/4pdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pdp RCSB], [https://www.ebi.ac.uk/pdbsum/4pdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pdp ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pdp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pdp RCSB], [http://www.ebi.ac.uk/pdbsum/4pdp PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAD53_YEAST RAD53_YEAST] Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. Seems to be involved in the phosphorylation of RPH1.<ref>PMID:8355715</ref> <ref>PMID:7958905</ref> <ref>PMID:10550056</ref> <ref>PMID:11809875</ref> <ref>PMID:15024067</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural basis of Rad53 kinase activation by dimerization and activation segment exchange.,Wybenga-Groot LE, Ho CS, Sweeney FD, Ceccarelli DF, Jane McGlade C, Durocher D, Sicheri F Cell Signal. 2014 May 9. pii: S0898-6568(14)00174-0. doi:, 10.1016/j.cellsig.2014.05.004. PMID:24815189<ref>PMID:24815189</ref>
Structural basis of Rad53 kinase activation by dimerization and activation segment exchange.,Wybenga-Groot LE, Ho CS, Sweeney FD, Ceccarelli DF, Jane McGlade C, Durocher D, Sicheri F Cell Signal. 2014 May 9. pii: S0898-6568(14)00174-0. doi:, 10.1016/j.cellsig.2014.05.004. PMID:24815189<ref>PMID:24815189</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4pdp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Protein kinase Spk1|Protein kinase Spk1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dual-specificity kinase]]
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[[Category: Large Structures]]
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[[Category: Ceccarelli, D F.]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Ho, C S.]]
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[[Category: Ceccarelli DF]]
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[[Category: Sicheri, F.]]
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[[Category: Ho CS]]
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[[Category: Wybenga-Groot, L E.]]
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[[Category: Sicheri F]]
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[[Category: Activation segment exchange]]
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[[Category: Wybenga-Groot LE]]
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[[Category: C-lobe]]
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[[Category: N-lobe]]
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[[Category: Ser/thr kinase domain]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Rad53 kinase domain and SCD2

PDB ID 4pdp

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