1ail

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[[Image:1ail.gif|left|200px]]
 
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{{Structure
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==N-TERMINAL FRAGMENT OF NS1 PROTEIN FROM INFLUENZA A VIRUS==
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|PDB= 1ail |SIZE=350|CAPTION= <scene name='initialview01'>1ail</scene>, resolution 1.9&Aring;
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<StructureSection load='1ail' size='340' side='right'caption='[[1ail]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1ail]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Udorn/307/1972(H3N2)) Influenza A virus (A/Udorn/307/1972(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AIL FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ail FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ail OCA], [https://pdbe.org/1ail PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ail RCSB], [https://www.ebi.ac.uk/pdbsum/1ail PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ail ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NS1_I72A2 NS1_I72A2] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). This results in the accumulation of unprocessed 3' end pre-mRNAs which can't be exported from the nucleus. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.<ref>PMID:9651582</ref> <ref>PMID:9560194</ref> <ref>PMID:16571812</ref> Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells (By similarity).<ref>PMID:9651582</ref> <ref>PMID:9560194</ref> <ref>PMID:16571812</ref>
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'''N-TERMINAL FRAGMENT OF NS1 PROTEIN FROM INFLUENZA A VIRUS'''
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==See Also==
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*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
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== References ==
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==Overview==
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<references/>
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The nonstructural protein (NS1 protein) of the influenza A virus binds to several types of RNAs. X-ray crystallographic analysis of the RNA-binding domain reveals a unique topology for the monomer as well as a novel six-helix structure for the dimer.
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1AIL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AIL OCA].
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[[Category: Berman HM]]
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[[Category: Chien C]]
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==Reference==
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[[Category: Krug RM]]
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Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein., Liu J, Lynch PA, Chien CY, Montelione GT, Krug RM, Berman HM, Nat Struct Biol. 1997 Nov;4(11):896-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9360602 9360602]
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[[Category: Liu J]]
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[[Category: Influenza a virus]]
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[[Category: Lynch PA]]
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[[Category: Single protein]]
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[[Category: Montelione GT]]
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[[Category: Berman, H M.]]
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[[Category: Chien, C.]]
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[[Category: Krug, R M.]]
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[[Category: Liu, J.]]
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[[Category: Lynch, P A.]]
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[[Category: Montelione, G T.]]
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[[Category: nonstructural protein]]
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[[Category: rna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:58:04 2008''
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Current revision

N-TERMINAL FRAGMENT OF NS1 PROTEIN FROM INFLUENZA A VIRUS

PDB ID 1ail

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