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4mji

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==T cell response to a HIV reverse transcriptase epitope presented by the protective allele HLA-B*51:01==
==T cell response to a HIV reverse transcriptase epitope presented by the protective allele HLA-B*51:01==
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<StructureSection load='4mji' size='340' side='right' caption='[[4mji]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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<StructureSection load='4mji' size='340' side='right'caption='[[4mji]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mji]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MJI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mji]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MJI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mji RCSB], [http://www.ebi.ac.uk/pdbsum/4mji PDBsum]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mji OCA], [https://pdbe.org/4mji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mji RCSB], [https://www.ebi.ac.uk/pdbsum/4mji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mji ProSAT]</span></td></tr>
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<table>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/1B51_HUMAN 1B51_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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[https://www.uniprot.org/uniprot/R4WL38_9HIV1 R4WL38_9HIV1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01.,Motozono C, Kuse N, Sun X, Rizkallah PJ, Fuller A, Oka S, Cole DK, Sewell AK, Takiguchi M J Immunol. 2014 Apr 1;192(7):3428-34. doi: 10.4049/jimmunol.1302667. Epub 2014, Mar 5. PMID:24600035<ref>PMID:24600035</ref>
Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01.,Motozono C, Kuse N, Sun X, Rizkallah PJ, Fuller A, Oka S, Cole DK, Sewell AK, Takiguchi M J Immunol. 2014 Apr 1;192(7):3428-34. doi: 10.4049/jimmunol.1302667. Epub 2014, Mar 5. PMID:24600035<ref>PMID:24600035</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4mji" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cole, D K.]]
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[[Category: Homo sapiens]]
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[[Category: Motozono, C.]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Rizkallah, P J.]]
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[[Category: Large Structures]]
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[[Category: Sewell, A K.]]
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[[Category: Cole DK]]
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[[Category: Takiguchi, M.]]
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[[Category: Motozono C]]
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[[Category: Antigen presentation]]
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[[Category: Rizkallah PJ]]
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[[Category: Class i mhc]]
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[[Category: Sewell AK]]
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[[Category: Hiv]]
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[[Category: Takiguchi M]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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[[Category: Peptide-major histocompatibility complex]]
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[[Category: Pmhc]]
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[[Category: Spr]]
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[[Category: Surface plasmon resonance]]
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[[Category: T-cell]]
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[[Category: T-cell receptor]]
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[[Category: Tcr]]
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Current revision

T cell response to a HIV reverse transcriptase epitope presented by the protective allele HLA-B*51:01

PDB ID 4mji

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