4o97

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==Crystal structure of matriptase in complex with inhibitor==
==Crystal structure of matriptase in complex with inhibitor==
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<StructureSection load='4o97' size='340' side='right' caption='[[4o97]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='4o97' size='340' side='right'caption='[[4o97]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4o97]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O97 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4o97]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O97 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NTX:N-(TRANS-4-AMINOCYCLOHEXYL)-3,5-BIS[(3-CARBAMIMIDOYLBENZYL)OXY]BENZAMIDE'>NTX</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o9v|4o9v]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NTX:N-(TRANS-4-AMINOCYCLOHEXYL)-3,5-BIS[(3-CARBAMIMIDOYLBENZYL)OXY]BENZAMIDE'>NTX</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Matriptase Matriptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.109 3.4.21.109] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o97 OCA], [https://pdbe.org/4o97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o97 RCSB], [https://www.ebi.ac.uk/pdbsum/4o97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o97 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o97 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o97 RCSB], [http://www.ebi.ac.uk/pdbsum/4o97 PDBsum]</span></td></tr>
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</table>
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<table>
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== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref>
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[https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[https://omim.org/entry/610765 610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
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[https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.,Goswami R, Mukherjee S, Ghadiyaram C, Wohlfahrt G, Sistla RK, Nagaraj J, Satyam LK, Subbarao K, Palakurthy RK, Gopinath S, Krishnamurthy NR, Ikonen T, Moilanen A, Subramanya HS, Kallio P, Ramachandra M Bioorg Med Chem. 2014 Jun 15;22(12):3187-203. doi: 10.1016/j.bmc.2014.04.013., Epub 2014 Apr 18. PMID:24794746<ref>PMID:24794746</ref>
Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.,Goswami R, Mukherjee S, Ghadiyaram C, Wohlfahrt G, Sistla RK, Nagaraj J, Satyam LK, Subbarao K, Palakurthy RK, Gopinath S, Krishnamurthy NR, Ikonen T, Moilanen A, Subramanya HS, Kallio P, Ramachandra M Bioorg Med Chem. 2014 Jun 15;22(12):3187-203. doi: 10.1016/j.bmc.2014.04.013., Epub 2014 Apr 18. PMID:24794746<ref>PMID:24794746</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4o97" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Matriptase 3D structures|Matriptase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Matriptase]]
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[[Category: Homo sapiens]]
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[[Category: Ashok, K N.]]
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[[Category: Large Structures]]
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[[Category: Chakshusmathi, G.]]
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[[Category: Ashok KN]]
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[[Category: Chandra, B R.]]
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[[Category: Chakshusmathi G]]
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[[Category: Ramesh, K S.]]
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[[Category: Chandra BR]]
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[[Category: Rao, K N.]]
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[[Category: Ramesh KS]]
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[[Category: Subramanya, H S.]]
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[[Category: Rao KN]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Subramanya HS]]
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[[Category: Matriptase]]
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[[Category: Protease]]
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[[Category: Small molecule inhibitor]]
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[[Category: Trypsin-like serine proteinase fold]]
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Current revision

Crystal structure of matriptase in complex with inhibitor

PDB ID 4o97

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