3lwe
From Proteopedia
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==The crystal structure of MPP8== | ==The crystal structure of MPP8== | ||
| - | <StructureSection load='3lwe' size='340' side='right' caption='[[3lwe]], [[Resolution|resolution]] 2.05Å' scene=''> | + | <StructureSection load='3lwe' size='340' side='right'caption='[[3lwe]], [[Resolution|resolution]] 2.05Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3lwe]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3lwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LWE FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwe OCA], [https://pdbe.org/3lwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lwe RCSB], [https://www.ebi.ac.uk/pdbsum/3lwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwe ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MPP8_HUMAN MPP8_HUMAN] Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.<ref>PMID:20871592</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwe_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwe_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lwe ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.,Li J, Li Z, Ruan J, Xu C, Tong Y, Pan PW, Tempel W, Crombet L, Min J, Zang J PLoS One. 2011;6(10):e25104. Epub 2011 Oct 12. PMID:22022377<ref>PMID:22022377</ref> | Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.,Li J, Li Z, Ruan J, Xu C, Tong Y, Pan PW, Tempel W, Crombet L, Min J, Zang J PLoS One. 2011;6(10):e25104. Epub 2011 Oct 12. PMID:22022377<ref>PMID:22022377</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 3lwe" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Crombet | + | [[Category: Large Structures]] |
| - | [[Category: Li | + | [[Category: Crombet L]] |
| - | [[Category: Min | + | [[Category: Li Z]] |
| - | [[Category: Pan | + | [[Category: Min J]] |
| - | [[Category: Ruan | + | [[Category: Pan PW]] |
| - | [[Category: Tempel | + | [[Category: Ruan J]] |
| - | [[Category: Tong | + | [[Category: Tempel W]] |
| - | [[Category: Xu | + | [[Category: Tong Y]] |
| - | [[Category: Zang | + | [[Category: Xu C]] |
| - | + | [[Category: Zang J]] | |
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Current revision
The crystal structure of MPP8
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Categories: Homo sapiens | Large Structures | Crombet L | Li Z | Min J | Pan PW | Ruan J | Tempel W | Tong Y | Xu C | Zang J
