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2lha

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==Solution structure of C2B with IP6==
==Solution structure of C2B with IP6==
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<StructureSection load='2lha' size='340' side='right' caption='[[2lha]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2lha' size='340' side='right'caption='[[2lha]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2lha]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LHA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2lha]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LHA FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SYT1, SVP65, SYT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lha OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lha RCSB], [http://www.ebi.ac.uk/pdbsum/2lha PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lha OCA], [https://pdbe.org/2lha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lha RCSB], [https://www.ebi.ac.uk/pdbsum/2lha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lha ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Molecular Level Interaction of Inositol Hexaphosphate with the C2B Domain of Human Synaptotagmin I.,Joung MJ, Mohan SK, Yu C Biochemistry. 2012 May 1;51(17):3675-83. Epub 2012 Apr 18. PMID:22475172<ref>PMID:22475172</ref>
Molecular Level Interaction of Inositol Hexaphosphate with the C2B Domain of Human Synaptotagmin I.,Joung MJ, Mohan SK, Yu C Biochemistry. 2012 May 1;51(17):3675-83. Epub 2012 Apr 18. PMID:22475172<ref>PMID:22475172</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2lha" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Joung, M.]]
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[[Category: Large Structures]]
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[[Category: Mohan, S K.]]
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[[Category: Joung M]]
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[[Category: Yu, C.]]
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[[Category: Mohan SK]]
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[[Category: Beta-sheet protein]]
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[[Category: Yu C]]
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[[Category: Calcium binding protein]]
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[[Category: Metal binding protein]]
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[[Category: Protein-drug complex]]
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Current revision

Solution structure of C2B with IP6

PDB ID 2lha

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