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User:John S. de Banzie/Globular Protein

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==Simple Example of Globular Protein Structure==
==Simple Example of Globular Protein Structure==
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<StructureSection load='1qgv' size='400' side='right' caption='U5 Spliceosomal protein, [[1qgv]]' scene='58/587846/U5-15kd_sf/1'>
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<StructureSection load='1qgv' size='400' side='right' caption='Human U5 Spliceosomal protein U5-15kD, [[1qgv]]' scene='58/587846/1qgv_sf/2'>
Most proteins are globular proteins. This page uses the human spliceosomal protein U5-15kD to illustrate some basic features of globular proteins. Specifically:
Most proteins are globular proteins. This page uses the human spliceosomal protein U5-15kD to illustrate some basic features of globular proteins. Specifically:
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3. Globular proteins have mixed secondary structure.
3. Globular proteins have mixed secondary structure.
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(U5-15kD is a component of the U5 small nuclear ribosomal protein particle (snRNP). This in turn is a component of the spliceosome, a macromolecule assembly involved in converting primary transcripts into functional mRNAs. U5-15kD was chosen for this page because it is small, but has the features necessary to illustrate the points being made.)
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(U5-15kD is a component of the U5 small nuclear ribosomal protein particle (snRNP). This in turn is a component of the spliceosome, a macromolecular assembly involved in converting primary transcripts into functional mRNAs. U5-15kD was chosen for this page because it is small, but has all of the features necessary to illustrate the points being made.)
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The <scene name='58/587846/U5-15kd_sf/1'>space filling model</scene> of the protein shows that the protein is compact, globular, and has no signs of internal cavities.
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The <scene name='58/587846/1qgv_sf/2'>space filling model</scene> of the protein shows that the protein is compact, globular, and has no signs of internal cavities.
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<scene name='58/587846/U5-15kd_phobicity/1'>Colouring the hydrophilic and hydrophobic residues</scene> shows that the interior of the protein is primarily hydrophobic (red) and the exterior is primarily hydrophilic (blue).
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Colouring the <scene name='58/587846/1qgv_sf_pnp/2'>hydrophilic and hydrophobic residues</scene> shows that the interior of the protein is primarily hydrophobic (red) and the exterior is primarily hydrophilic (blue).
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The <scene name='58/587846/U5-15kd_ca/1'>cartoon view</scene> of the protein shows that the protein has mixed secondary structure. There are three segments of alpha-helix (magenta), six segments of beta-pleated sheet (gold), and some irregular regions (white).
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The <scene name='58/587846/1qgv_ca/2'>cartoon view</scene> of the protein shows that the protein has mixed secondary structure. There are three segments of alpha-helix (magenta), six segments of beta-pleated sheet (gold), both parallel and anti-parallel, and some irregular regions (white).

Current revision

Simple Example of Globular Protein Structure

Human U5 Spliceosomal protein U5-15kD, 1qgv

Drag the structure with the mouse to rotate

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John S. de Banzie

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