3j6f

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==Minimized average structure of GDP-bound dynamic microtubules==
==Minimized average structure of GDP-bound dynamic microtubules==
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<StructureSection load='3j6f' size='340' side='right' caption='[[3j6f]], [[Resolution|resolution]] 4.90&Aring;' scene=''>
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<SX load='3j6f' size='340' side='right' viewer='molstar' caption='[[3j6f]], [[Resolution|resolution]] 4.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3j6f]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J6F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3j6f]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6F FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.9&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3j6e|3j6e]], [[3j6g|3j6g]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j6f RCSB], [http://www.ebi.ac.uk/pdbsum/3j6f PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6f OCA], [https://pdbe.org/3j6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6f RCSB], [https://www.ebi.ac.uk/pdbsum/3j6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6f ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TBA1A_PIG TBA1A_PIG] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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High-Resolution Microtubule Structures Reveal the Structural Transitions in alphabeta-Tubulin upon GTP Hydrolysis.,Alushin GM, Lander GC, Kellogg EH, Zhang R, Baker D, Nogales E Cell. 2014 May 22;157(5):1117-29. doi: 10.1016/j.cell.2014.03.053. PMID:24855948<ref>PMID:24855948</ref>
High-Resolution Microtubule Structures Reveal the Structural Transitions in alphabeta-Tubulin upon GTP Hydrolysis.,Alushin GM, Lander GC, Kellogg EH, Zhang R, Baker D, Nogales E Cell. 2014 May 22;157(5):1117-29. doi: 10.1016/j.cell.2014.03.053. PMID:24855948<ref>PMID:24855948</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3j6f" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Alushin, G M.]]
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[[Category: Alushin GM]]
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[[Category: Baker, D.]]
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[[Category: Baker D]]
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[[Category: Kellogg, E H.]]
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[[Category: Kellogg EH]]
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[[Category: Lander, G C.]]
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[[Category: Lander GC]]
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[[Category: Nogales, E.]]
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[[Category: Nogales E]]
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[[Category: Zhang, R.]]
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[[Category: Zhang R]]
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[[Category: Dynamic]]
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[[Category: Gdp]]
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[[Category: Microtubule]]
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[[Category: Structural protein]]
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Current revision

Minimized average structure of GDP-bound dynamic microtubules

3j6f, resolution 4.90Å

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