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4nyc

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==Crystal structure of the E. coli thiM riboswitch in complex with thieno[2,3-b]pyrazin-7-amine==
==Crystal structure of the E. coli thiM riboswitch in complex with thieno[2,3-b]pyrazin-7-amine==
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<StructureSection load='4nyc' size='340' side='right' caption='[[4nyc]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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<StructureSection load='4nyc' size='340' side='right'caption='[[4nyc]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nyc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NYC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nyc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NYC FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SVN:THIENO[2,3-B]PYRAZIN-7-AMINE'>SVN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SVN:THIENO[2,3-B]PYRAZIN-7-AMINE'>SVN</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nya|4nya]], [[4nyb|4nyb]], [[4nyd|4nyd]], [[4nyg|4nyg]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nyc OCA], [https://pdbe.org/4nyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nyc RCSB], [https://www.ebi.ac.uk/pdbsum/4nyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nyc ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nyc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nyc RCSB], [http://www.ebi.ac.uk/pdbsum/4nyc PDBsum]</span></td></tr>
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</table>
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<table>
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<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically.,Warner KD, Homan P, Weeks KM, Smith AG, Abell C, Ferre-D'Amare AR Chem Biol. 2014 May 22;21(5):591-5. doi: 10.1016/j.chembiol.2014.03.007. Epub, 2014 Apr 24. PMID:24768306<ref>PMID:24768306</ref>
Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically.,Warner KD, Homan P, Weeks KM, Smith AG, Abell C, Ferre-D'Amare AR Chem Biol. 2014 May 22;21(5):591-5. doi: 10.1016/j.chembiol.2014.03.007. Epub, 2014 Apr 24. PMID:24768306<ref>PMID:24768306</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4nyc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Riboswitch 3D structures|Riboswitch 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Abell, C.]]
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[[Category: Escherichia coli]]
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[[Category: Amare, A R.Ferre-D.]]
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[[Category: Large Structures]]
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[[Category: Homan, P.]]
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[[Category: Abell C]]
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[[Category: Smith, A G.]]
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[[Category: Ferre-D'Amare AR]]
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[[Category: Warner, K D.]]
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[[Category: Homan P]]
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[[Category: Weeks, K M.]]
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[[Category: Smith AG]]
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[[Category: Fragment-based drug discovery]]
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[[Category: Warner KD]]
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[[Category: Riboswitch]]
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[[Category: Weeks KM]]
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[[Category: Rna]]
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Crystal structure of the E. coli thiM riboswitch in complex with thieno[2,3-b]pyrazin-7-amine

PDB ID 4nyc

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