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3ppc

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==Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, tyrosine variant with zinc==
==Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, tyrosine variant with zinc==
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<StructureSection load='3ppc' size='340' side='right' caption='[[3ppc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='3ppc' size='340' side='right'caption='[[3ppc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ppc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PPC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ppc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PPC FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pph|3pph]], [[3ppf|3ppf]], [[3ppg|3ppg]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CaO19.10083, CaO19.2551, MET6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ppc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppc OCA], [https://pdbe.org/3ppc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ppc RCSB], [https://www.ebi.ac.uk/pdbsum/3ppc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppc ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-methyltetrahydropteroyltriglutamate--homocysteine_S-methyltransferase 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.14 2.1.1.14] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ppc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ppc RCSB], [http://www.ebi.ac.uk/pdbsum/3ppc PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/METE_CANAL METE_CANAL] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis.,Ubhi D, Kavanagh KL, Monzingo AF, Robertus JD Arch Biochem Biophys. 2011 Sep 1;513(1):19-26. doi:, 10.1016/j.abb.2011.06.002. Epub 2011 Jun 12. PMID:21689631<ref>PMID:21689631</ref>
Structure of Candida albicans methionine synthase determined by employing surface residue mutagenesis.,Ubhi D, Kavanagh KL, Monzingo AF, Robertus JD Arch Biochem Biophys. 2011 Sep 1;513(1):19-26. doi:, 10.1016/j.abb.2011.06.002. Epub 2011 Jun 12. PMID:21689631<ref>PMID:21689631</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3ppc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Methionine synthase 3D structures|Methionine synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]
 
[[Category: Candida albicans]]
[[Category: Candida albicans]]
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[[Category: Kavanagh, K.]]
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[[Category: Large Structures]]
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[[Category: Monzingo, A F.]]
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[[Category: Kavanagh K]]
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[[Category: Robertus, J D.]]
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[[Category: Monzingo AF]]
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[[Category: Ubhi, D.]]
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[[Category: Robertus JD]]
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[[Category: Cobalamin-independent]]
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[[Category: Ubhi D]]
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[[Category: Surface entropy reduction]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the Candida albicans methionine synthase by surface entropy reduction, tyrosine variant with zinc

PDB ID 3ppc

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