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3psl

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==Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic==
==Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic==
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<StructureSection load='3psl' size='340' side='right' caption='[[3psl]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='3psl' size='340' side='right'caption='[[3psl]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3psl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PSL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3psl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PSL FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3psl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3psl RCSB], [http://www.ebi.ac.uk/pdbsum/3psl PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3psl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psl OCA], [https://pdbe.org/3psl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3psl RCSB], [https://www.ebi.ac.uk/pdbsum/3psl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3psl ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.,Avdic V, Zhang P, Lanouette S, Voronova A, Skerjanc I, Couture JF FASEB J. 2010 Dec 6. PMID:21135039<ref>PMID:21135039</ref>
Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.,Avdic V, Zhang P, Lanouette S, Voronova A, Skerjanc I, Couture JF FASEB J. 2010 Dec 6. PMID:21135039<ref>PMID:21135039</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3psl" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Avdic, V.]]
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[[Category: Large Structures]]
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[[Category: Couture, J F.]]
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[[Category: Avdic V]]
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[[Category: Lanouette, S.]]
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[[Category: Couture J-F]]
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[[Category: Skerjanc, I.]]
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[[Category: Lanouette S]]
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[[Category: Voronova, A.]]
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[[Category: Skerjanc I]]
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[[Category: Zhang, P.]]
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[[Category: Voronova A]]
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[[Category: Beta-propeller]]
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[[Category: Zhang P]]
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[[Category: Chromatin]]
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[[Category: Histone]]
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[[Category: Mll1]]
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[[Category: Nucleus]]
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[[Category: Rbbp5]]
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[[Category: Scaffolding]]
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[[Category: Transcription - transcription inhibitor complex]]
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[[Category: Transcription-transcription inhibitor complex]]
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Current revision

Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic

PDB ID 3psl

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