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3rsn
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==Crystal Structure of the N-terminal region of Human Ash2L== | ==Crystal Structure of the N-terminal region of Human Ash2L== | ||
| - | <StructureSection load='3rsn' size='340' side='right' caption='[[3rsn]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='3rsn' size='340' side='right'caption='[[3rsn]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3rsn]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3rsn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RSN FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASH2L, ASH2L1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASH2L, ASH2L1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rsn OCA], [https://pdbe.org/3rsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rsn RCSB], [https://www.ebi.ac.uk/pdbsum/3rsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rsn ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ASH2L_HUMAN ASH2L_HUMAN]] Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.<ref>PMID:12670868</ref> <ref>PMID:19556245</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.,Chen Y, Wan B, Wang KC, Cao F, Yang Y, Protacio A, Dou Y, Chang HY, Lei M EMBO Rep. 2011 Jun 10. doi: 10.1038/embor.2011.101. PMID:21660059<ref>PMID:21660059</ref> | Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.,Chen Y, Wan B, Wang KC, Cao F, Yang Y, Protacio A, Dou Y, Chang HY, Lei M EMBO Rep. 2011 Jun 10. doi: 10.1038/embor.2011.101. PMID:21660059<ref>PMID:21660059</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | <div class="pdbe-citations 3rsn" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Histone methyltransferase|Histone methyltransferase]] | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Cao, F | + | [[Category: Large Structures]] |
| - | [[Category: Chang, H Y | + | [[Category: Cao, F]] |
| - | [[Category: Chen, Y | + | [[Category: Chang, H Y]] |
| - | [[Category: Dou, Y | + | [[Category: Chen, Y]] |
| - | [[Category: Lei, M | + | [[Category: Dou, Y]] |
| - | [[Category: Protacio, A | + | [[Category: Lei, M]] |
| - | [[Category: Wan, B | + | [[Category: Protacio, A]] |
| - | [[Category: Wang, K C | + | [[Category: Wan, B]] |
| - | [[Category: Yang, Y | + | [[Category: Wang, K C]] |
| + | [[Category: Yang, Y]] | ||
[[Category: Dna binding]] | [[Category: Dna binding]] | ||
[[Category: Histone methyltransferase]] | [[Category: Histone methyltransferase]] | ||
Current revision
Crystal Structure of the N-terminal region of Human Ash2L
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Categories: Human | Large Structures | Cao, F | Chang, H Y | Chen, Y | Dou, Y | Lei, M | Protacio, A | Wan, B | Wang, K C | Yang, Y | Dna binding | Histone methyltransferase | Phd domain | Transcription | Winged helix domain
