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3r4d

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==Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor==
==Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor==
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<StructureSection load='3r4d' size='340' side='right' caption='[[3r4d]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='3r4d' size='340' side='right'caption='[[3r4d]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3r4d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Murine_hepatitis_virus Murine hepatitis virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R4D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3r4d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [https://en.wikipedia.org/wiki/Murine_coronavirus Murine coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R4D FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ajf|2ajf]], [[3kbh|3kbh]], [[1l6z|1l6z]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ajf|2ajf]], [[3kbh|3kbh]], [[1l6z|1l6z]]</div></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ceacam1, CEACAM1a-2S, mCG_126985 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), ORF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11138 Murine hepatitis virus])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ceacam1, CEACAM1a-2S ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r4d RCSB], [http://www.ebi.ac.uk/pdbsum/3r4d PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r4d OCA], [https://pdbe.org/3r4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r4d RCSB], [https://www.ebi.ac.uk/pdbsum/3r4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r4d ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/S5ZBM1_9BETC S5ZBM1_9BETC]] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor.,Peng G, Sun D, Rajashankar KR, Qian Z, Holmes KV, Li F Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10696-701. Epub 2011 Jun 13. PMID:21670291<ref>PMID:21670291</ref>
Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor.,Peng G, Sun D, Rajashankar KR, Qian Z, Holmes KV, Li F Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10696-701. Epub 2011 Jun 13. PMID:21670291<ref>PMID:21670291</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3r4d" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Murine hepatitis virus]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Holmes, K V.]]
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[[Category: Murine coronavirus]]
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[[Category: Holmes, K V]]
[[Category: Li, F]]
[[Category: Li, F]]
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[[Category: Peng, G Q.]]
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[[Category: Peng, G Q]]
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[[Category: Qian, Z H.]]
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[[Category: Qian, Z H]]
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[[Category: Rajashankar, K R.]]
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[[Category: Rajashankar, K R]]
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[[Category: Sun, D W.]]
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[[Category: Sun, D W]]
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[[Category: 55]]
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[[Category: 70 mhv spike ntd - 192]]
[[Category: 70 mhv spike ntd - 192]]
[[Category: Beta-sandwich]]
[[Category: Beta-sandwich]]

Current revision

Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor

PDB ID 3r4d

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