3r6s

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==Crystal structure of GlxR transcription factor from Corynebacterium glutamicum with cAMP==
==Crystal structure of GlxR transcription factor from Corynebacterium glutamicum with cAMP==
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<StructureSection load='3r6s' size='340' side='right' caption='[[3r6s]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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<StructureSection load='3r6s' size='340' side='right'caption='[[3r6s]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3r6s]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R6S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3r6s]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R6S FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cg0350, cg0350 (glxR), Cgl0291 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1718 Corynebacterium glutamicum])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r6s RCSB], [http://www.ebi.ac.uk/pdbsum/3r6s PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r6s OCA], [https://pdbe.org/3r6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r6s RCSB], [https://www.ebi.ac.uk/pdbsum/3r6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r6s ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CRPL_CORGL CRPL_CORGL] Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. Involved in the regulation of gntP and gntK genes, which are involved in gluconate metabolism (PubMed:16385030). May form dimers which bind to the aceB promoter region in the presence of cAMP and repress the glyoxylate bypass genes (PubMed:15150232). It could be a positive regulator of rpf2 gene expression during growth on acetate as the sole carbon source, however because the cytosolic cAMP level is elevated in the presence of glucose and low upon growth on acetate, it is conceivable that it is unable to function as an activator under acetate conditions (PubMed:18355281).<ref>PMID:15150232</ref> <ref>PMID:16385030</ref> <ref>PMID:18355281</ref>
==See Also==
==See Also==
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*[[Transcriptional activator|Transcriptional activator]]
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Corynebacterium glutamicum]]
[[Category: Corynebacterium glutamicum]]
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[[Category: Jungwirth, B.]]
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[[Category: Large Structures]]
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[[Category: Pojer, F.]]
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[[Category: Jungwirth B]]
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[[Category: C-terminal hth-motif]]
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[[Category: Pojer F]]
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[[Category: Homodimer]]
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[[Category: N-terminal camp-binding domain]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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Current revision

Crystal structure of GlxR transcription factor from Corynebacterium glutamicum with cAMP

PDB ID 3r6s

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