3sqi

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==DNA binding domain of Ndc10==
==DNA binding domain of Ndc10==
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<StructureSection load='3sqi' size='340' side='right' caption='[[3sqi]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
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<StructureSection load='3sqi' size='340' side='right'caption='[[3sqi]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3sqi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Kluyveromyces_lactis Kluyveromyces lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SQI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SQI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3sqi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SQI FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLLA0E03807g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28985 Kluyveromyces lactis])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8245&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sqi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sqi RCSB], [http://www.ebi.ac.uk/pdbsum/3sqi PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sqi OCA], [https://pdbe.org/3sqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sqi RCSB], [https://www.ebi.ac.uk/pdbsum/3sqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sqi ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6CPM4_KLULA Q6CPM4_KLULA]
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Kinetochores link centromeric DNA to spindle microtubules and ensure faithful chromosome segregation during mitosis. In point-centromere yeasts, the CBF3 complex Skp1-Ctf13-(Cep3)(2)-(Ndc10)(2) recognizes a conserved centromeric DNA element through contacts made by Cep3 and Ndc10. We describe here the five-domain organization of Kluyveromyces lactis Ndc10 and the structure at 2.8 A resolution of domains I-II (residues 1-402) bound to DNA. The structure resembles tyrosine DNA recombinases, although it lacks both endonuclease and ligase activities. Structural and biochemical data demonstrate that each subunit of the Ndc10 dimer binds a separate fragment of DNA, suggesting that Ndc10 stabilizes a DNA loop at the centromere. We describe in vitro association experiments showing that specific domains of Ndc10 interact with each of the known inner-kinetochore proteins or protein complexes in budding yeast. We propose that Ndc10 provides a central platform for inner-kinetochore assembly.
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Ndc10 is a platform for inner kinetochore assembly in budding yeast.,Cho US, Harrison SC Nat Struct Mol Biol. 2011 Dec 4. doi: 10.1038/nsmb.2178. PMID:22139014<ref>PMID:22139014</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kluyveromyces lactis]]
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[[Category: Kluyveromyces lactis NRRL Y-1140]]
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[[Category: Cho, U S.]]
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[[Category: Large Structures]]
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[[Category: Harrison, S C.]]
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[[Category: Cho US]]
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[[Category: Dna]]
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[[Category: Harrison SC]]
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[[Category: Dna binding]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Dna recombinase]]
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Current revision

DNA binding domain of Ndc10

PDB ID 3sqi

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