3sfv

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==Crystal structure of the GDP-bound Rab1a S25N mutant in complex with the coiled-coil domain of LidA from Legionella pneumophila==
==Crystal structure of the GDP-bound Rab1a S25N mutant in complex with the coiled-coil domain of LidA from Legionella pneumophila==
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<StructureSection load='3sfv' size='340' side='right' caption='[[3sfv]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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<StructureSection load='3sfv' size='340' side='right'caption='[[3sfv]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3sfv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SFV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3sfv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Legionella_pneumophila_str._Corby Legionella pneumophila str. Corby]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SFV FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAB1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), lidA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 Legionella pneumophila])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sfv RCSB], [http://www.ebi.ac.uk/pdbsum/3sfv PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfv OCA], [https://pdbe.org/3sfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sfv RCSB], [https://www.ebi.ac.uk/pdbsum/3sfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sfv ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAB1A_HUMAN RAB1A_HUMAN] Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State.,Cheng W, Yin K, Lu D, Li B, Zhu D, Chen Y, Zhang H, Xu S, Chai J, Gu L PLoS Pathog. 2012 Mar;8(3):e1002528. Epub 2012 Mar 1. PMID:22416225<ref>PMID:22416225</ref>
Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State.,Cheng W, Yin K, Lu D, Li B, Zhu D, Chen Y, Zhang H, Xu S, Chai J, Gu L PLoS Pathog. 2012 Mar;8(3):e1002528. Epub 2012 Mar 1. PMID:22416225<ref>PMID:22416225</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3sfv" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Legionella pneumophila]]
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[[Category: Large Structures]]
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[[Category: Gu, L.]]
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[[Category: Legionella pneumophila str. Corby]]
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[[Category: Li, B.]]
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[[Category: Gu L]]
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[[Category: Lu, D.]]
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[[Category: Li B]]
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[[Category: Xu, S.]]
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[[Category: Lu D]]
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[[Category: Yin, K.]]
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[[Category: Xu S]]
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[[Category: Zhang, H.]]
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[[Category: Yin K]]
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[[Category: Zhu, D.]]
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[[Category: Zhang H]]
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[[Category: Coiled-coil domain]]
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[[Category: Zhu D]]
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[[Category: Gdp binding]]
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[[Category: Lida-rab complex]]
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[[Category: Protein transport-protein binding complex]]
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[[Category: Type iv effector protein from legionella]]
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Current revision

Crystal structure of the GDP-bound Rab1a S25N mutant in complex with the coiled-coil domain of LidA from Legionella pneumophila

PDB ID 3sfv

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